A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.

Research output: Contribution to journalArticle

314 Scopus citations

Abstract

The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.

Original languageEnglish (US)
Pages (from-to)6368-6370
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number11
StatePublished - Nov 1980
Externally publishedYes

ASJC Scopus subject areas

  • General
  • Genetics

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