Abstract
A P157S mutation in the reverse transcriptase (RT) of human immunodeficiency virus type 1 conferred fivefold resistance to (-)-β-2',3'- dideoxy-3'-thiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity (two- to threefold) to 3'-azido-3'- deoxythymidine (AZT) and to (R)-9-(2-phosphonyimethoxypropyl)adenine (PMPA). A similar increase in susceptibility to AZT and to PMPA was also conferred by the M184V mutation in RT.
Original language | English (US) |
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Pages (from-to) | 2077-2080 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 43 |
Issue number | 8 |
State | Published - Aug 1999 |
ASJC Scopus subject areas
- Pharmacology (medical)