Abstract
A P157S mutation in the reverse transcriptase (RT) of human immunodeficiency virus type 1 conferred fivefold resistance to (-)-β-2',3'- dideoxy-3'-thiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity (two- to threefold) to 3'-azido-3'- deoxythymidine (AZT) and to (R)-9-(2-phosphonyimethoxypropyl)adenine (PMPA). A similar increase in susceptibility to AZT and to PMPA was also conferred by the M184V mutation in RT.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2077-2080 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 43 |
| Issue number | 8 |
| State | Published - Aug 1999 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-β-2',3'- dideoxy-3'-thiacytidine. / Smith, Robert A.; Klarmann, George J.; Stray, Kirsten M.; Von Schwedler, Uta K.; Schinazi, Raymond F.; Preston, Bradley D.; North, Thomas W.
In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 8, 08.1999, p. 2077-2080.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-β-2',3'- dideoxy-3'-thiacytidine
AU - Smith, Robert A.
AU - Klarmann, George J.
AU - Stray, Kirsten M.
AU - Von Schwedler, Uta K.
AU - Schinazi, Raymond F.
AU - Preston, Bradley D.
AU - North, Thomas W.
PY - 1999/8
Y1 - 1999/8
N2 - A P157S mutation in the reverse transcriptase (RT) of human immunodeficiency virus type 1 conferred fivefold resistance to (-)-β-2',3'- dideoxy-3'-thiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity (two- to threefold) to 3'-azido-3'- deoxythymidine (AZT) and to (R)-9-(2-phosphonyimethoxypropyl)adenine (PMPA). A similar increase in susceptibility to AZT and to PMPA was also conferred by the M184V mutation in RT.
AB - A P157S mutation in the reverse transcriptase (RT) of human immunodeficiency virus type 1 conferred fivefold resistance to (-)-β-2',3'- dideoxy-3'-thiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity (two- to threefold) to 3'-azido-3'- deoxythymidine (AZT) and to (R)-9-(2-phosphonyimethoxypropyl)adenine (PMPA). A similar increase in susceptibility to AZT and to PMPA was also conferred by the M184V mutation in RT.
UR - http://www.scopus.com/inward/record.url?scp=0032817243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032817243&partnerID=8YFLogxK
M3 - Article
C2 - 10428942
AN - SCOPUS:0032817243
VL - 43
SP - 2077
EP - 2080
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 8
ER -