A new perspective on glucocorticoid feedback

Relation to stress, carbohydrate feeding and feeling better

Kevin D. Laugero

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Input to and regulation of activity in the hypothalamic-pituitary-adrenal (HPA) axis is diverse and complex. Glucocorticoid feedback is a major component that determines activity in this classic neuroendocrine axis and, while feedback occurs through the brain, the pathways that mediate glucocorticoid feedback remain unknown. In this review, I discuss findings that have led us to view glucocorticoid feedback in the HPA axis in a new light. Much of what has precipitated this view comes from a very surprising finding in our laboratory; sucrose ingestion normalizes feeding, energy balance and central corticotropin releasing factor expression in adrenalectomized (ADX) rats. Since this discovery, a diverse set of literature that supports this view of glucocorticoid feedback has been found. Taken together, recent findings of the well-known importance of glucocorticoids to feeding and energy balance, and the modulatory actions of carbohydrate ingestion on both basal and stress-induced activity in the HPA axis, strongly suggest that many metabolic (e.g. obesity) and psychological (e.g. depression) pathologies, which often present together and have been associated with stress and HPA dysregulation, might, in part, be understood in light of our new view of glucocorticoid feedback.

Original languageEnglish (US)
Pages (from-to)827-835
Number of pages9
JournalJournal of Neuroendocrinology
Volume13
Issue number9
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Glucocorticoids
Emotions
Carbohydrates
Eating
Corticotropin-Releasing Hormone
Sucrose
Obesity
Depression
Pathology
Psychology
Brain

Keywords

  • CRF
  • Energy balance
  • HPA axis
  • Model
  • Sucrose ingestion

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

A new perspective on glucocorticoid feedback : Relation to stress, carbohydrate feeding and feeling better. / Laugero, Kevin D.

In: Journal of Neuroendocrinology, Vol. 13, No. 9, 2001, p. 827-835.

Research output: Contribution to journalArticle

@article{1dbf836f8ed44b7aa0d170d221fac9f2,
title = "A new perspective on glucocorticoid feedback: Relation to stress, carbohydrate feeding and feeling better",
abstract = "Input to and regulation of activity in the hypothalamic-pituitary-adrenal (HPA) axis is diverse and complex. Glucocorticoid feedback is a major component that determines activity in this classic neuroendocrine axis and, while feedback occurs through the brain, the pathways that mediate glucocorticoid feedback remain unknown. In this review, I discuss findings that have led us to view glucocorticoid feedback in the HPA axis in a new light. Much of what has precipitated this view comes from a very surprising finding in our laboratory; sucrose ingestion normalizes feeding, energy balance and central corticotropin releasing factor expression in adrenalectomized (ADX) rats. Since this discovery, a diverse set of literature that supports this view of glucocorticoid feedback has been found. Taken together, recent findings of the well-known importance of glucocorticoids to feeding and energy balance, and the modulatory actions of carbohydrate ingestion on both basal and stress-induced activity in the HPA axis, strongly suggest that many metabolic (e.g. obesity) and psychological (e.g. depression) pathologies, which often present together and have been associated with stress and HPA dysregulation, might, in part, be understood in light of our new view of glucocorticoid feedback.",
keywords = "CRF, Energy balance, HPA axis, Model, Sucrose ingestion",
author = "Laugero, {Kevin D.}",
year = "2001",
doi = "10.1046/j.1365-2826.2001.00706.x",
language = "English (US)",
volume = "13",
pages = "827--835",
journal = "Journal of Neuroendocrinology",
issn = "0953-8194",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - A new perspective on glucocorticoid feedback

T2 - Relation to stress, carbohydrate feeding and feeling better

AU - Laugero, Kevin D.

PY - 2001

Y1 - 2001

N2 - Input to and regulation of activity in the hypothalamic-pituitary-adrenal (HPA) axis is diverse and complex. Glucocorticoid feedback is a major component that determines activity in this classic neuroendocrine axis and, while feedback occurs through the brain, the pathways that mediate glucocorticoid feedback remain unknown. In this review, I discuss findings that have led us to view glucocorticoid feedback in the HPA axis in a new light. Much of what has precipitated this view comes from a very surprising finding in our laboratory; sucrose ingestion normalizes feeding, energy balance and central corticotropin releasing factor expression in adrenalectomized (ADX) rats. Since this discovery, a diverse set of literature that supports this view of glucocorticoid feedback has been found. Taken together, recent findings of the well-known importance of glucocorticoids to feeding and energy balance, and the modulatory actions of carbohydrate ingestion on both basal and stress-induced activity in the HPA axis, strongly suggest that many metabolic (e.g. obesity) and psychological (e.g. depression) pathologies, which often present together and have been associated with stress and HPA dysregulation, might, in part, be understood in light of our new view of glucocorticoid feedback.

AB - Input to and regulation of activity in the hypothalamic-pituitary-adrenal (HPA) axis is diverse and complex. Glucocorticoid feedback is a major component that determines activity in this classic neuroendocrine axis and, while feedback occurs through the brain, the pathways that mediate glucocorticoid feedback remain unknown. In this review, I discuss findings that have led us to view glucocorticoid feedback in the HPA axis in a new light. Much of what has precipitated this view comes from a very surprising finding in our laboratory; sucrose ingestion normalizes feeding, energy balance and central corticotropin releasing factor expression in adrenalectomized (ADX) rats. Since this discovery, a diverse set of literature that supports this view of glucocorticoid feedback has been found. Taken together, recent findings of the well-known importance of glucocorticoids to feeding and energy balance, and the modulatory actions of carbohydrate ingestion on both basal and stress-induced activity in the HPA axis, strongly suggest that many metabolic (e.g. obesity) and psychological (e.g. depression) pathologies, which often present together and have been associated with stress and HPA dysregulation, might, in part, be understood in light of our new view of glucocorticoid feedback.

KW - CRF

KW - Energy balance

KW - HPA axis

KW - Model

KW - Sucrose ingestion

UR - http://www.scopus.com/inward/record.url?scp=0034827643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034827643&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2826.2001.00706.x

DO - 10.1046/j.1365-2826.2001.00706.x

M3 - Article

VL - 13

SP - 827

EP - 835

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 9

ER -