Abstract
Input to and regulation of activity in the hypothalamic-pituitary-adrenal (HPA) axis is diverse and complex. Glucocorticoid feedback is a major component that determines activity in this classic neuroendocrine axis and, while feedback occurs through the brain, the pathways that mediate glucocorticoid feedback remain unknown. In this review, I discuss findings that have led us to view glucocorticoid feedback in the HPA axis in a new light. Much of what has precipitated this view comes from a very surprising finding in our laboratory; sucrose ingestion normalizes feeding, energy balance and central corticotropin releasing factor expression in adrenalectomized (ADX) rats. Since this discovery, a diverse set of literature that supports this view of glucocorticoid feedback has been found. Taken together, recent findings of the well-known importance of glucocorticoids to feeding and energy balance, and the modulatory actions of carbohydrate ingestion on both basal and stress-induced activity in the HPA axis, strongly suggest that many metabolic (e.g. obesity) and psychological (e.g. depression) pathologies, which often present together and have been associated with stress and HPA dysregulation, might, in part, be understood in light of our new view of glucocorticoid feedback.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 827-835 |
| Number of pages | 9 |
| Journal | Journal of Neuroendocrinology |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- CRF
- Energy balance
- HPA axis
- Model
- Sucrose ingestion
ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
Cite this
A new perspective on glucocorticoid feedback : Relation to stress, carbohydrate feeding and feeling better. / Laugero, Kevin D.
In: Journal of Neuroendocrinology, Vol. 13, No. 9, 2001, p. 827-835.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A new perspective on glucocorticoid feedback
T2 - Relation to stress, carbohydrate feeding and feeling better
AU - Laugero, Kevin D.
PY - 2001
Y1 - 2001
N2 - Input to and regulation of activity in the hypothalamic-pituitary-adrenal (HPA) axis is diverse and complex. Glucocorticoid feedback is a major component that determines activity in this classic neuroendocrine axis and, while feedback occurs through the brain, the pathways that mediate glucocorticoid feedback remain unknown. In this review, I discuss findings that have led us to view glucocorticoid feedback in the HPA axis in a new light. Much of what has precipitated this view comes from a very surprising finding in our laboratory; sucrose ingestion normalizes feeding, energy balance and central corticotropin releasing factor expression in adrenalectomized (ADX) rats. Since this discovery, a diverse set of literature that supports this view of glucocorticoid feedback has been found. Taken together, recent findings of the well-known importance of glucocorticoids to feeding and energy balance, and the modulatory actions of carbohydrate ingestion on both basal and stress-induced activity in the HPA axis, strongly suggest that many metabolic (e.g. obesity) and psychological (e.g. depression) pathologies, which often present together and have been associated with stress and HPA dysregulation, might, in part, be understood in light of our new view of glucocorticoid feedback.
AB - Input to and regulation of activity in the hypothalamic-pituitary-adrenal (HPA) axis is diverse and complex. Glucocorticoid feedback is a major component that determines activity in this classic neuroendocrine axis and, while feedback occurs through the brain, the pathways that mediate glucocorticoid feedback remain unknown. In this review, I discuss findings that have led us to view glucocorticoid feedback in the HPA axis in a new light. Much of what has precipitated this view comes from a very surprising finding in our laboratory; sucrose ingestion normalizes feeding, energy balance and central corticotropin releasing factor expression in adrenalectomized (ADX) rats. Since this discovery, a diverse set of literature that supports this view of glucocorticoid feedback has been found. Taken together, recent findings of the well-known importance of glucocorticoids to feeding and energy balance, and the modulatory actions of carbohydrate ingestion on both basal and stress-induced activity in the HPA axis, strongly suggest that many metabolic (e.g. obesity) and psychological (e.g. depression) pathologies, which often present together and have been associated with stress and HPA dysregulation, might, in part, be understood in light of our new view of glucocorticoid feedback.
KW - CRF
KW - Energy balance
KW - HPA axis
KW - Model
KW - Sucrose ingestion
UR - http://www.scopus.com/inward/record.url?scp=0034827643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034827643&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2826.2001.00706.x
DO - 10.1046/j.1365-2826.2001.00706.x
M3 - Article
C2 - 11578533
AN - SCOPUS:0034827643
VL - 13
SP - 827
EP - 835
JO - Journal of Neuroendocrinology
JF - Journal of Neuroendocrinology
SN - 0953-8194
IS - 9
ER -