A new method for the treatment of chronic fungal meningitis: Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis

Carol D. Berry, David A. Stevens, Eric I. Hassid, Demosthenes Pappagianis, Edie L. Happs, Kamran Sahrakar

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalAmerican Journal of the Medical Sciences
Volume338
Issue number1
DOIs
StatePublished - Jul 2009

    Fingerprint

Keywords

  • Amphotericin B
  • Antifungal therapy
  • Coccidioidomycosis
  • Fungal meningitis
  • Intrathecal therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this