A new method for the treatment of chronic fungal meningitis: Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis

Carol D. Berry; David A. Stevens; Eric I. Hassid; Demosthenes Pappagianis; Edie L. Happs; Kamran Sahrakar

doi:10.1097/MAJ.0b013e3181a3dac8

A new method for the treatment of chronic fungal meningitis: Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis

Carol D. Berry, David A. Stevens, Eric I. Hassid, Demosthenes Pappagianis, Edie L. Happs, Kamran Sahrakar

Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.

Original language	English (US)
Pages (from-to)	79-82
Number of pages	4
Journal	American Journal of the Medical Sciences
Volume	338
Issue number	1
DOIs	https://doi.org/10.1097/MAJ.0b013e3181a3dac8
State	Published - Jul 2009

Keywords

Amphotericin B
Antifungal therapy
Coccidioidomycosis
Fungal meningitis
Intrathecal therapy

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1097/MAJ.0b013e3181a3dac8

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A new method for the treatment of chronic fungal meningitis : Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. / Berry, Carol D.; Stevens, David A.; Hassid, Eric I.; Pappagianis, Demosthenes; Happs, Edie L.; Sahrakar, Kamran.

In: American Journal of the Medical Sciences, Vol. 338, No. 1, 07.2009, p. 79-82.

Research output: Contribution to journal › Article › peer-review

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