A new method for the treatment of chronic fungal meningitis: Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis

Carol D. Berry; David A. Stevens; Eric I. Hassid; Demosthenes Pappagianis; Edie L. Happs; Kamran Sahrakar

doi:10.1097/MAJ.0b013e3181a3dac8

A new method for the treatment of chronic fungal meningitis: Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis

Carol D. Berry, David A. Stevens, Eric I. Hassid, Demosthenes Pappagianis, Edie L. Happs, Kamran Sahrakar

Medical Microbiology and Immunology

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.

Original language	English (US)
Pages (from-to)	79-82
Number of pages	4
Journal	American Journal of the Medical Sciences
Volume	338
Issue number	1
DOIs	https://doi.org/10.1097/MAJ.0b013e3181a3dac8
State	Published - Jul 2009

Fingerprint

Keywords

Amphotericin B
Antifungal therapy
Coccidioidomycosis
Fungal meningitis
Intrathecal therapy

ASJC Scopus subject areas

Medicine(all)

Cite this

Berry, C. D., Stevens, D. A., Hassid, E. I., Pappagianis, D., Happs, E. L., & Sahrakar, K. (2009). A new method for the treatment of chronic fungal meningitis: Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. American Journal of the Medical Sciences, 338(1), 79-82. https://doi.org/10.1097/MAJ.0b013e3181a3dac8

A new method for the treatment of chronic fungal meningitis : Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. / Berry, Carol D.; Stevens, David A.; Hassid, Eric I.; Pappagianis, Demosthenes; Happs, Edie L.; Sahrakar, Kamran.

In: American Journal of the Medical Sciences, Vol. 338, No. 1, 07.2009, p. 79-82.

Research output: Contribution to journal › Article

@article{c9ede899c79642ac92df51a619bf068b,

title = "A new method for the treatment of chronic fungal meningitis: Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis",

abstract = "Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.",

keywords = "Amphotericin B, Antifungal therapy, Coccidioidomycosis, Fungal meningitis, Intrathecal therapy",

author = "Berry, {Carol D.} and Stevens, {David A.} and Hassid, {Eric I.} and Demosthenes Pappagianis and Happs, {Edie L.} and Kamran Sahrakar",

year = "2009",

month = jul

doi = "10.1097/MAJ.0b013e3181a3dac8",

language = "English (US)",

volume = "338",

pages = "79--82",

journal = "American Journal of the Medical Sciences",

issn = "0002-9629",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - A new method for the treatment of chronic fungal meningitis

T2 - Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis

AU - Berry, Carol D.

AU - Stevens, David A.

AU - Hassid, Eric I.

AU - Pappagianis, Demosthenes

AU - Happs, Edie L.

AU - Sahrakar, Kamran

PY - 2009/7

Y1 - 2009/7

N2 - Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.

AB - Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.

KW - Amphotericin B

KW - Antifungal therapy

KW - Coccidioidomycosis

KW - Fungal meningitis

KW - Intrathecal therapy

UR - http://www.scopus.com/inward/record.url?scp=68849095256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68849095256&partnerID=8YFLogxK

U2 - 10.1097/MAJ.0b013e3181a3dac8

DO - 10.1097/MAJ.0b013e3181a3dac8

M3 - Article

C2 - 19506457

AN - SCOPUS:68849095256

VL - 338

SP - 79

EP - 82

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 1

ER -

Access to Document

10.1097/MAJ.0b013e3181a3dac8