Abstract
Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 79-82 |
| Number of pages | 4 |
| Journal | American Journal of the Medical Sciences |
| Volume | 338 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2009 |
Fingerprint
Keywords
- Amphotericin B
- Antifungal therapy
- Coccidioidomycosis
- Fungal meningitis
- Intrathecal therapy
ASJC Scopus subject areas
- Medicine(all)
Cite this
A new method for the treatment of chronic fungal meningitis : Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. / Berry, Carol D.; Stevens, David A.; Hassid, Eric I.; Pappagianis, Demosthenes; Happs, Edie L.; Sahrakar, Kamran.
In: American Journal of the Medical Sciences, Vol. 338, No. 1, 07.2009, p. 79-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A new method for the treatment of chronic fungal meningitis
T2 - Continuous infusion into the cerebrospinal fluid for coccidioidal meningitis
AU - Berry, Carol D.
AU - Stevens, David A.
AU - Hassid, Eric I.
AU - Pappagianis, Demosthenes
AU - Happs, Edie L.
AU - Sahrakar, Kamran
PY - 2009/7
Y1 - 2009/7
N2 - Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.
AB - Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.
KW - Amphotericin B
KW - Antifungal therapy
KW - Coccidioidomycosis
KW - Fungal meningitis
KW - Intrathecal therapy
UR - http://www.scopus.com/inward/record.url?scp=68849095256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68849095256&partnerID=8YFLogxK
U2 - 10.1097/MAJ.0b013e3181a3dac8
DO - 10.1097/MAJ.0b013e3181a3dac8
M3 - Article
C2 - 19506457
AN - SCOPUS:68849095256
VL - 338
SP - 79
EP - 82
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 1
ER -