Abstract
Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use of this modality, which is a promising novel avenue of therapy for chronic meningitis.
Original language | English (US) |
---|---|
Pages (from-to) | 79-82 |
Number of pages | 4 |
Journal | American Journal of the Medical Sciences |
Volume | 338 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2009 |
Keywords
- Amphotericin B
- Antifungal therapy
- Coccidioidomycosis
- Fungal meningitis
- Intrathecal therapy
ASJC Scopus subject areas
- Medicine(all)