A new imaging strategy utilizing wideband transient response of ultrasound contrast agents

Dustin E. Kruse, Chih Kuang Yeh, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

High resolution clinical systems operating near 15 MHz are becoming more available, however, they lack sensitive harmonic imaging modes for ultrasound contrast agent (UCA) detection, primarily due to limited bandwidth. When an UCA is driven to non-linear oscillation, a very wideband acoustic transient response is produced that extends beyond 15 MHz. We propose a novel strategy utilizing 2 separate transducers at widely separated frequencies and arranged confocally to simultaneously excite and receive acoustic transients from UCAs. Experiments were performed to demonstrate that this new mode shows similar resolution, higher echo amplitudes and greatly reduced attenuation compared to transmission at a higher frequency, and superior resolution compared to transmission and reception at a lower frequency. The proposed method is shown to resolve two 200 μm tubes with centers separated by 400 μm. Strong acoustic transients were detected for rarefaction-first 1-cycle pulses starting at peak-negative pressures ranging from -300 to -400 kPa. The results of this work may lead to uses in flow and/or targeted imaging in applications requiring very high sensitivity to contrast agents.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsD.E. Yuhas, S.C. Schneider
Pages424-428
Number of pages5
Volume1
StatePublished - 2003
Event2003 IEEE Ultrasonics Symposium - Proceedings - Honolulu, HI, United States
Duration: Oct 5 2003Oct 8 2003

Other

Other2003 IEEE Ultrasonics Symposium - Proceedings
CountryUnited States
CityHonolulu, HI
Period10/5/0310/8/03

Fingerprint

Transient analysis
Ultrasonics
Acoustics
Imaging techniques
Transducers
Bandwidth
Experiments

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Kruse, D. E., Yeh, C. K., & Ferrara, K. W. (2003). A new imaging strategy utilizing wideband transient response of ultrasound contrast agents. In D. E. Yuhas, & S. C. Schneider (Eds.), Proceedings of the IEEE Ultrasonics Symposium (Vol. 1, pp. 424-428)

A new imaging strategy utilizing wideband transient response of ultrasound contrast agents. / Kruse, Dustin E.; Yeh, Chih Kuang; Ferrara, Katherine W.

Proceedings of the IEEE Ultrasonics Symposium. ed. / D.E. Yuhas; S.C. Schneider. Vol. 1 2003. p. 424-428.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kruse, DE, Yeh, CK & Ferrara, KW 2003, A new imaging strategy utilizing wideband transient response of ultrasound contrast agents. in DE Yuhas & SC Schneider (eds), Proceedings of the IEEE Ultrasonics Symposium. vol. 1, pp. 424-428, 2003 IEEE Ultrasonics Symposium - Proceedings, Honolulu, HI, United States, 10/5/03.
Kruse DE, Yeh CK, Ferrara KW. A new imaging strategy utilizing wideband transient response of ultrasound contrast agents. In Yuhas DE, Schneider SC, editors, Proceedings of the IEEE Ultrasonics Symposium. Vol. 1. 2003. p. 424-428
Kruse, Dustin E. ; Yeh, Chih Kuang ; Ferrara, Katherine W. / A new imaging strategy utilizing wideband transient response of ultrasound contrast agents. Proceedings of the IEEE Ultrasonics Symposium. editor / D.E. Yuhas ; S.C. Schneider. Vol. 1 2003. pp. 424-428
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