Abstract
BLM, the helicase implicated in Bloom's syndrome, and its yeast counterpart Sgs1 function in complexes with a type 1 topoisomerase to resolve double Holliday junctions to form non-crossover products. These data provide a direct explanation for the highly elevated sister chromatid exchange frequency in Bloom's syndrome cells.
Original language | English (US) |
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Pages (from-to) | 117-119 |
Number of pages | 3 |
Journal | Nature Structural and Molecular Biology |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2004 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology