A new deal for Holliday junctions

Wolf Dietrich Heyer

doi:10.1038/nsmb0204-117

A new deal for Holliday junctions

Wolf Dietrich Heyer

Microbiology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

BLM, the helicase implicated in Bloom's syndrome, and its yeast counterpart Sgs1 function in complexes with a type 1 topoisomerase to resolve double Holliday junctions to form non-crossover products. These data provide a direct explanation for the highly elevated sister chromatid exchange frequency in Bloom's syndrome cells.

Original language	English (US)
Pages (from-to)	117-119
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1038/nsmb0204-117
State	Published - Feb 2004

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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abstract = "BLM, the helicase implicated in Bloom's syndrome, and its yeast counterpart Sgs1 function in complexes with a type 1 topoisomerase to resolve double Holliday junctions to form non-crossover products. These data provide a direct explanation for the highly elevated sister chromatid exchange frequency in Bloom's syndrome cells.",

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