A new deal for Holliday junctions

Wolf Dietrich Heyer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

BLM, the helicase implicated in Bloom's syndrome, and its yeast counterpart Sgs1 function in complexes with a type 1 topoisomerase to resolve double Holliday junctions to form non-crossover products. These data provide a direct explanation for the highly elevated sister chromatid exchange frequency in Bloom's syndrome cells.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalNature Structural and Molecular Biology
Volume11
Issue number2
DOIs
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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