A new biofilm story in biliary tract infection

J. Y. Sung, Joseph Leung, J. W. Costerton

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Acute cholangitis is commonly caused by biliary obstruction due to gallstones blocking the bile ducts and to malignancies of the biliary and pancreatic system. The pathogenesis of brown pigment gallstones, blockage of biliary stents, and biliary parasitic infestation are related to the formation of bacterial biofilms. Biliary pathogens, such as Escherichia coli and other enteric organisms, attach themselves to the surface of an ulcerated biliary mucosa or implanted biomaterial to form a bacterial biofilm. Some of these bacteria produce enzymes (β-glucuronidase and phospholipid A1) and glycocalyx material that aid colonization and infestation. Crystals of calcium bilirubinate and other biliary sediments accumulate around the bacterial microcolonies and glycoproteins, forming adherent bacterial biofilms. The thick and often calcified biofilms obstruct the normal bile flow and lead to cholangitis.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalInternational Biodeterioration and Biodegradation
Volume30
Issue number2-3
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Biofilms
Biliary Tract
biofilm
Cholangitis
Gallstones
Infection
Glycocalyx
Glycoproteins
Stents
Glucuronidase
Phospholipids
Biocompatible Materials
Pathogens
Bile Ducts
phospholipid
Bilirubin
Biomaterials
Pigments
Bile
Ducts

ASJC Scopus subject areas

  • Environmental Science(all)
  • Microbiology

Cite this

A new biofilm story in biliary tract infection. / Sung, J. Y.; Leung, Joseph; Costerton, J. W.

In: International Biodeterioration and Biodegradation, Vol. 30, No. 2-3, 1992, p. 155-165.

Research output: Contribution to journalArticle

Sung, J. Y. ; Leung, Joseph ; Costerton, J. W. / A new biofilm story in biliary tract infection. In: International Biodeterioration and Biodegradation. 1992 ; Vol. 30, No. 2-3. pp. 155-165.
@article{0d9bad1d30e747328d81a939ea134517,
title = "A new biofilm story in biliary tract infection",
abstract = "Acute cholangitis is commonly caused by biliary obstruction due to gallstones blocking the bile ducts and to malignancies of the biliary and pancreatic system. The pathogenesis of brown pigment gallstones, blockage of biliary stents, and biliary parasitic infestation are related to the formation of bacterial biofilms. Biliary pathogens, such as Escherichia coli and other enteric organisms, attach themselves to the surface of an ulcerated biliary mucosa or implanted biomaterial to form a bacterial biofilm. Some of these bacteria produce enzymes (β-glucuronidase and phospholipid A1) and glycocalyx material that aid colonization and infestation. Crystals of calcium bilirubinate and other biliary sediments accumulate around the bacterial microcolonies and glycoproteins, forming adherent bacterial biofilms. The thick and often calcified biofilms obstruct the normal bile flow and lead to cholangitis.",
author = "Sung, {J. Y.} and Joseph Leung and Costerton, {J. W.}",
year = "1992",
doi = "10.1016/0964-8305(92)90060-2",
language = "English (US)",
volume = "30",
pages = "155--165",
journal = "International Biodeterioration and Biodegradation",
issn = "0964-8305",
publisher = "Elsevier Limited",
number = "2-3",

}

TY - JOUR

T1 - A new biofilm story in biliary tract infection

AU - Sung, J. Y.

AU - Leung, Joseph

AU - Costerton, J. W.

PY - 1992

Y1 - 1992

N2 - Acute cholangitis is commonly caused by biliary obstruction due to gallstones blocking the bile ducts and to malignancies of the biliary and pancreatic system. The pathogenesis of brown pigment gallstones, blockage of biliary stents, and biliary parasitic infestation are related to the formation of bacterial biofilms. Biliary pathogens, such as Escherichia coli and other enteric organisms, attach themselves to the surface of an ulcerated biliary mucosa or implanted biomaterial to form a bacterial biofilm. Some of these bacteria produce enzymes (β-glucuronidase and phospholipid A1) and glycocalyx material that aid colonization and infestation. Crystals of calcium bilirubinate and other biliary sediments accumulate around the bacterial microcolonies and glycoproteins, forming adherent bacterial biofilms. The thick and often calcified biofilms obstruct the normal bile flow and lead to cholangitis.

AB - Acute cholangitis is commonly caused by biliary obstruction due to gallstones blocking the bile ducts and to malignancies of the biliary and pancreatic system. The pathogenesis of brown pigment gallstones, blockage of biliary stents, and biliary parasitic infestation are related to the formation of bacterial biofilms. Biliary pathogens, such as Escherichia coli and other enteric organisms, attach themselves to the surface of an ulcerated biliary mucosa or implanted biomaterial to form a bacterial biofilm. Some of these bacteria produce enzymes (β-glucuronidase and phospholipid A1) and glycocalyx material that aid colonization and infestation. Crystals of calcium bilirubinate and other biliary sediments accumulate around the bacterial microcolonies and glycoproteins, forming adherent bacterial biofilms. The thick and often calcified biofilms obstruct the normal bile flow and lead to cholangitis.

UR - http://www.scopus.com/inward/record.url?scp=0026961205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026961205&partnerID=8YFLogxK

U2 - 10.1016/0964-8305(92)90060-2

DO - 10.1016/0964-8305(92)90060-2

M3 - Article

AN - SCOPUS:0026961205

VL - 30

SP - 155

EP - 165

JO - International Biodeterioration and Biodegradation

JF - International Biodeterioration and Biodegradation

SN - 0964-8305

IS - 2-3

ER -