A new attachment/cleavage strategy: Polymer-bound allylic sulfones in a solid-phase route to trisubstituted olefins

Chris Halm; Jerry Evarts; Mark J. Kurth

doi:10.1016/S0040-4039(97)10062-4

A new attachment/cleavage strategy: Polymer-bound allylic sulfones in a solid-phase route to trisubstituted olefins

Chris Halm, Jerry Evarts, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

By tethering allyl sulfone to polystyrene (3-steps from polystyrene beads consisting of lithiation, sulfination, and allylation), trisubstituted olefins can be generated by Cα-sulfone alkylation and subsequent resin cleavage by S(N)2' nucleophilic displacement of sulfinate.

Original language	English (US)
Pages (from-to)	7709-7712
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	44
DOIs	https://doi.org/10.1016/S0040-4039(97)10062-4
State	Published - Nov 3 1997

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/S0040-4039(97)10062-4

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title = "A new attachment/cleavage strategy: Polymer-bound allylic sulfones in a solid-phase route to trisubstituted olefins",

abstract = "By tethering allyl sulfone to polystyrene (3-steps from polystyrene beads consisting of lithiation, sulfination, and allylation), trisubstituted olefins can be generated by Cα-sulfone alkylation and subsequent resin cleavage by S(N)2' nucleophilic displacement of sulfinate.",

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AU - Evarts, Jerry

AU - Kurth, Mark J.

PY - 1997/11/3

Y1 - 1997/11/3

N2 - By tethering allyl sulfone to polystyrene (3-steps from polystyrene beads consisting of lithiation, sulfination, and allylation), trisubstituted olefins can be generated by Cα-sulfone alkylation and subsequent resin cleavage by S(N)2' nucleophilic displacement of sulfinate.

AB - By tethering allyl sulfone to polystyrene (3-steps from polystyrene beads consisting of lithiation, sulfination, and allylation), trisubstituted olefins can be generated by Cα-sulfone alkylation and subsequent resin cleavage by S(N)2' nucleophilic displacement of sulfinate.

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A new attachment/cleavage strategy: Polymer-bound allylic sulfones in a solid-phase route to trisubstituted olefins

Abstract

ASJC Scopus subject areas

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