A new attachment/cleavage strategy: Polymer-bound allylic sulfones in a solid-phase route to trisubstituted olefins

Chris Halm, Jerry Evarts, Mark J. Kurth

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

By tethering allyl sulfone to polystyrene (3-steps from polystyrene beads consisting of lithiation, sulfination, and allylation), trisubstituted olefins can be generated by Cα-sulfone alkylation and subsequent resin cleavage by S(N)2' nucleophilic displacement of sulfinate.

Original languageEnglish (US)
Pages (from-to)7709-7712
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number44
DOIs
StatePublished - Nov 3 1997

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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