A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Johannes W. de Jong, Seyedeh Atiyeh Afjei, Iskra Pollak Dorocic, James R. Peck, Christine Liu, Christina K. Kim, Lin Tian, Karl Deisseroth, Stephan Lammel

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The mesolimbic dopamine system plays an important role in reward, reinforcement learning and motivated behaviors. de Jong et al. reveal a circuit mechanism that implicates a subtype of mesolimbic dopamine neurons in the encoding of aversive-predicting stimuli.

Original languageEnglish (US)
Pages (from-to)133-151.e7
JournalNeuron
Volume101
Issue number1
DOIs
StatePublished - Jan 2 2019

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Keywords

  • aversion
  • dopamine
  • dorsal raphe
  • lateral hypothalamus
  • nucleus accumbens
  • reward
  • ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

de Jong, J. W., Afjei, S. A., Pollak Dorocic, I., Peck, J. R., Liu, C., Kim, C. K., Tian, L., Deisseroth, K., & Lammel, S. (2019). A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System. Neuron, 101(1), 133-151.e7. https://doi.org/10.1016/j.neuron.2018.11.005