A nanoindentation technique for functional evaluation of cartilage repair tissue

Donna M. Ebenstein, Alfred Kuo, Juan J. Rodrigo, A Hari Reddi, Michael Ries, Lisa Pruitt

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Cartilage repair is an ongoing challenge in orthopaedic research. Both biological and mechanical properties are needed for full functional characterization of a tissue replacement. However, assessment of cartilage repair tissue has relied primarily on histological markers because mechanical properties are difficult to measure in small tissue regions. Nanoindentation is a technique that is specialized for measuring local mechanical properties in small specimens. In this study, nanoindentation was used to measure the mechanical properties of cartilage repair tissue following microfracture treatment of chondral defects in three rabbit knees. The mechanical properties were then correlated with histology findings from the same tissue samples. Nanoindentation provided complementary information to histology. In particular, the nanoindentation results showed that the mechanical properties of the repair tissue were inferior to the control tissue properties, even though some tissue regions were histologically similar to the control tissue.

Original languageEnglish (US)
Pages (from-to)273-281
Number of pages9
JournalJournal of Materials Research
Volume19
Issue number1
StatePublished - Jan 2004

Fingerprint

cartilage
Cartilage
Nanoindentation
nanoindentation
Repair
Tissue
evaluation
mechanical properties
Mechanical properties
Histology
histology
orthopedics
rabbits
Orthopedics
markers
Defects
defects

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Ebenstein, D. M., Kuo, A., Rodrigo, J. J., Reddi, A. H., Ries, M., & Pruitt, L. (2004). A nanoindentation technique for functional evaluation of cartilage repair tissue. Journal of Materials Research, 19(1), 273-281.

A nanoindentation technique for functional evaluation of cartilage repair tissue. / Ebenstein, Donna M.; Kuo, Alfred; Rodrigo, Juan J.; Reddi, A Hari; Ries, Michael; Pruitt, Lisa.

In: Journal of Materials Research, Vol. 19, No. 1, 01.2004, p. 273-281.

Research output: Contribution to journalArticle

Ebenstein, DM, Kuo, A, Rodrigo, JJ, Reddi, AH, Ries, M & Pruitt, L 2004, 'A nanoindentation technique for functional evaluation of cartilage repair tissue', Journal of Materials Research, vol. 19, no. 1, pp. 273-281.
Ebenstein, Donna M. ; Kuo, Alfred ; Rodrigo, Juan J. ; Reddi, A Hari ; Ries, Michael ; Pruitt, Lisa. / A nanoindentation technique for functional evaluation of cartilage repair tissue. In: Journal of Materials Research. 2004 ; Vol. 19, No. 1. pp. 273-281.
@article{c8378bc065ee42988442e85026e1ee6d,
title = "A nanoindentation technique for functional evaluation of cartilage repair tissue",
abstract = "Cartilage repair is an ongoing challenge in orthopaedic research. Both biological and mechanical properties are needed for full functional characterization of a tissue replacement. However, assessment of cartilage repair tissue has relied primarily on histological markers because mechanical properties are difficult to measure in small tissue regions. Nanoindentation is a technique that is specialized for measuring local mechanical properties in small specimens. In this study, nanoindentation was used to measure the mechanical properties of cartilage repair tissue following microfracture treatment of chondral defects in three rabbit knees. The mechanical properties were then correlated with histology findings from the same tissue samples. Nanoindentation provided complementary information to histology. In particular, the nanoindentation results showed that the mechanical properties of the repair tissue were inferior to the control tissue properties, even though some tissue regions were histologically similar to the control tissue.",
author = "Ebenstein, {Donna M.} and Alfred Kuo and Rodrigo, {Juan J.} and Reddi, {A Hari} and Michael Ries and Lisa Pruitt",
year = "2004",
month = "1",
language = "English (US)",
volume = "19",
pages = "273--281",
journal = "Journal of Materials Research",
issn = "0884-2914",
publisher = "Materials Research Society",
number = "1",

}

TY - JOUR

T1 - A nanoindentation technique for functional evaluation of cartilage repair tissue

AU - Ebenstein, Donna M.

AU - Kuo, Alfred

AU - Rodrigo, Juan J.

AU - Reddi, A Hari

AU - Ries, Michael

AU - Pruitt, Lisa

PY - 2004/1

Y1 - 2004/1

N2 - Cartilage repair is an ongoing challenge in orthopaedic research. Both biological and mechanical properties are needed for full functional characterization of a tissue replacement. However, assessment of cartilage repair tissue has relied primarily on histological markers because mechanical properties are difficult to measure in small tissue regions. Nanoindentation is a technique that is specialized for measuring local mechanical properties in small specimens. In this study, nanoindentation was used to measure the mechanical properties of cartilage repair tissue following microfracture treatment of chondral defects in three rabbit knees. The mechanical properties were then correlated with histology findings from the same tissue samples. Nanoindentation provided complementary information to histology. In particular, the nanoindentation results showed that the mechanical properties of the repair tissue were inferior to the control tissue properties, even though some tissue regions were histologically similar to the control tissue.

AB - Cartilage repair is an ongoing challenge in orthopaedic research. Both biological and mechanical properties are needed for full functional characterization of a tissue replacement. However, assessment of cartilage repair tissue has relied primarily on histological markers because mechanical properties are difficult to measure in small tissue regions. Nanoindentation is a technique that is specialized for measuring local mechanical properties in small specimens. In this study, nanoindentation was used to measure the mechanical properties of cartilage repair tissue following microfracture treatment of chondral defects in three rabbit knees. The mechanical properties were then correlated with histology findings from the same tissue samples. Nanoindentation provided complementary information to histology. In particular, the nanoindentation results showed that the mechanical properties of the repair tissue were inferior to the control tissue properties, even though some tissue regions were histologically similar to the control tissue.

UR - http://www.scopus.com/inward/record.url?scp=4444222980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444222980&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:4444222980

VL - 19

SP - 273

EP - 281

JO - Journal of Materials Research

JF - Journal of Materials Research

SN - 0884-2914

IS - 1

ER -