A multiple detector array helical x-ray microtomography system for specimen imaging

Neva M. Corrigan, Andres E. Chavez, Erik R Wisner, John M Boone

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

An x-ray computed microtomography system for specimen and small animal imaging was built and tested. The system used seventeen 48-μm-wide detector arrays (a charge coupled device camera) and helical acquisition techniques. Images were acquired using 540 rays/view and 400 views/2π. The modulation transfer function (MTF) of the computed tomography images demonstrated 50 μm limiting resolution, with MTF> 10% for objects larger than 60 μm (~8.3 cycles/mm). While soft tissue discrimination was compromised by a low signal- to-noise ratio, equine medullary bone core samples and the murine skeleton were well visualized. The incorporation of multiple detector arrays provided a 17-fold improvement in x-ray efficiency, which is a very important step toward improving the potential of microtomography as a scientific tool.

Original languageEnglish (US)
Pages (from-to)1708-1713
Number of pages6
JournalMedical Physics
Volume26
Issue number8
DOIs
StatePublished - Aug 1999

Keywords

  • Computed tomography
  • Helical CT
  • Instrumentation
  • Microtomography
  • Mouse

ASJC Scopus subject areas

  • Biophysics

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