A multinational study of α-lactalbumin concentrations in human milk

Joan G. Jackson, Derek B. Janszen, Bo Lonnerdal, Eric L. Lien, Kathryn P. Pramuk, Charles F. Kuhlman

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

α-Lactalbumin, a 14-kD protein, plays a central biochemical role in the mammary gland as the regulatory subunit of lactose synthase, and also plays a nutritional role for the rapidly growing neonate as the protein in highest concentration in human milk. The current study was undertaken to better characterize α-lactalbumin concentrations in human milk from a variety of countries. Mature human milk (lactation duration ≥1 month) was collected from at least 50 women from nine different countries on five continents. α-Lactalbumin concentration was determined by HPLC. The mean ± SD for 452 samples was 2.44 ± 0.64 g/L. The mean value of the samples from the United States was significantly higher than that from any other country, and the mean in Mexico was significantly lower than that from every country except China and Canada. α-Lactalbumin concentration decreased with increasing duration of lactation and was positively correlated with total nitrogen. On average, α-lactalbumin contributed 16% of the total nitrogen content of human milk and consequently an important part of the amino acid content.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalJournal of Nutritional Biochemistry
Volume15
Issue number9
DOIs
StatePublished - Sep 2004

Fingerprint

Lactalbumin
Human Milk
Lactation
Lactose Synthase
Nitrogen
Human Mammary Glands
Mexico
Canada
China
Proteins
High Pressure Liquid Chromatography
Newborn Infant
Amino Acids

Keywords

  • HPLC
  • Lactalbumin
  • Mature human milk
  • Multi-country variation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Jackson, J. G., Janszen, D. B., Lonnerdal, B., Lien, E. L., Pramuk, K. P., & Kuhlman, C. F. (2004). A multinational study of α-lactalbumin concentrations in human milk. Journal of Nutritional Biochemistry, 15(9), 517-521. https://doi.org/10.1016/j.jnutbio.2003.10.009

A multinational study of α-lactalbumin concentrations in human milk. / Jackson, Joan G.; Janszen, Derek B.; Lonnerdal, Bo; Lien, Eric L.; Pramuk, Kathryn P.; Kuhlman, Charles F.

In: Journal of Nutritional Biochemistry, Vol. 15, No. 9, 09.2004, p. 517-521.

Research output: Contribution to journalArticle

Jackson, JG, Janszen, DB, Lonnerdal, B, Lien, EL, Pramuk, KP & Kuhlman, CF 2004, 'A multinational study of α-lactalbumin concentrations in human milk', Journal of Nutritional Biochemistry, vol. 15, no. 9, pp. 517-521. https://doi.org/10.1016/j.jnutbio.2003.10.009
Jackson, Joan G. ; Janszen, Derek B. ; Lonnerdal, Bo ; Lien, Eric L. ; Pramuk, Kathryn P. ; Kuhlman, Charles F. / A multinational study of α-lactalbumin concentrations in human milk. In: Journal of Nutritional Biochemistry. 2004 ; Vol. 15, No. 9. pp. 517-521.
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