A multimodal imaging analysis of subcortical gray matter in fragile X premutation carriers

Jun Yi Wang, Randi J Hagerman, Susan M. Rivera

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Approximately 40% of males with the fragile X premutation develop fragile X-associated tremor/ataxia syndrome after age 50. Although the thalamus and basal ganglia play a crucial role in movement disorders, their involvement in fragile X premutation carriers has not been systematically investigated. The current study characterized structural abnormalities associated with fragile X premutation carriers (with and without fragile X-associated tremor/ataxia syndrome) in the thalamus, caudate nucleus, putamen, and globus pallidus using T1-weighted and diffusion tensor imaging. Male premutation carriers with fragile X-associated tremor/ataxia syndrome showed significant volume atrophy and diffusion-weighted signal loss in all 4 structures compared with the control group. They also exhibited volume atrophy and diffusion-weighted signal loss in the thalamus and striatum compared with the premutation carriers without fragile X-associated tremor/ataxia syndrome. Importantly, many of the measurements exhibited robust correlations with symptom severity, with volume and diffusion-weighted imaging measurements displaying negative correlations and fractional anisotropy measurements displaying positive correlations. The current study demonstrated involvement of all 4 subcortical gray matter structures in fragile X-associated tremor/ataxia syndrome, with significant volume atrophy, and possible iron deposition indicated by the diffusion-weighted signal loss. The significant correlation between the subcortical measurements and symptom severity suggests the benefits of tracking structural changes in subcortical gray matter in future longitudinal studies for early detection and disease monitoring.

Original languageEnglish (US)
Pages (from-to)1278-1284
Number of pages7
JournalMovement Disorders
Volume28
Issue number9
DOIs
StatePublished - Aug 2013

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Multimodal Imaging
Thalamus
Atrophy
Globus Pallidus
Diffusion Tensor Imaging
Caudate Nucleus
Putamen
Anisotropy
Movement Disorders
Basal Ganglia
Longitudinal Studies
Early Diagnosis
Iron
Fragile X Tremor Ataxia Syndrome
Gray Matter
Control Groups

Keywords

  • Diffusion tensor imaging
  • Diffusion-weighted imaging
  • Genetic disorder
  • Iron dysregulation
  • Neurodegeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

A multimodal imaging analysis of subcortical gray matter in fragile X premutation carriers. / Wang, Jun Yi; Hagerman, Randi J; Rivera, Susan M.

In: Movement Disorders, Vol. 28, No. 9, 08.2013, p. 1278-1284.

Research output: Contribution to journalArticle

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