A multiethnic study of Δ32ccr5 and ccr2b-V64I allele distribution in four Los Angeles populations

Ramaswamy K. Iyer, Phillip S. Kim, Joanne M. Bando, Kan V. Lu, Jeffrey Gregg, Wayne W. Grody

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mutant alleles of the chemokine receptors CCR5 and CCR2 affect the susceptibility to HIV infection as well as the rate of disease progression. In this article the authors report the results of a survey for presence of the common Δ32ccr5 and ccr2b-V64I mutant alleles in 472 individuals of a multiethnic cohort. Hispanic Americans had the highest observed frequency of the Δ32ccr5 allele (3.57%), whereas African Americans had a lower frequency (1.55%). The mutant allele was absent in Asian Americans and Native Americans. Thus, the Δ32ccr5 allele segregates in populations with a significant white admixture and is rare in genetically distant non-European groups. Native Americans had the highest occurrence of the ccr2b-V64I allele (31.13%), whereas African Americans, Asian Americans, and Hispanic Americans had much lower frequencies (14.36%, 11.94%, and 14.37% respectively). This mutation is probably an ancient one, occurring before the migration of the ancestors of Native Americans across the Bering Straits to the Americas. The twofold greater frequency of ccr2b-V64I in moderm Native Americans probably reflects a founder effect. The observed population differences in Δ32ccr5 and ccr2b-V64I frequencies, considered together with their documented effects on sensitivity to HIV infection and rate of disease progression, have implications for HIV transmission patterns in the United States, as well as for AIDS prediction, monitoring, and treatment.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalDiagnostic Molecular Pathology
Volume10
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Los Angeles
North American Indians
Alleles
Asian Americans
Population
Hispanic Americans
African Americans
HIV Infections
Disease Progression
Founder Effect
Chemokine Receptors
Gene Frequency
Acquired Immunodeficiency Syndrome
HIV
Mutation

Keywords

  • Chemokine receptors
  • Disease progression
  • Ethnic stratification
  • Founder effect
  • HIV/AIDS

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A multiethnic study of Δ32ccr5 and ccr2b-V64I allele distribution in four Los Angeles populations. / Iyer, Ramaswamy K.; Kim, Phillip S.; Bando, Joanne M.; Lu, Kan V.; Gregg, Jeffrey; Grody, Wayne W.

In: Diagnostic Molecular Pathology, Vol. 10, No. 2, 2001, p. 105-110.

Research output: Contribution to journalArticle

Iyer, Ramaswamy K. ; Kim, Phillip S. ; Bando, Joanne M. ; Lu, Kan V. ; Gregg, Jeffrey ; Grody, Wayne W. / A multiethnic study of Δ32ccr5 and ccr2b-V64I allele distribution in four Los Angeles populations. In: Diagnostic Molecular Pathology. 2001 ; Vol. 10, No. 2. pp. 105-110.
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