TY - JOUR
T1 - A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment
AU - Nel, Andre E.
AU - Nasser, Elina
AU - Godwin, Hilary
AU - Avery, David
AU - Bahadori, Tina
AU - Bergeson, Lynn
AU - Beryt, Elizabeth
AU - Bonner, James C.
AU - Boverhof, Darrell
AU - Carter, Janet
AU - Castranova, Vince
AU - Deshazo, J. R.
AU - Hussain, Saber M.
AU - Kane, Agnes B.
AU - Klaessig, Frederick
AU - Kuempel, Eileen
AU - Lafranconi, Mark
AU - Landsiedel, Robert
AU - Malloy, Timothy
AU - Miller, Mary Beth
AU - Morris, Jeffery
AU - Moss, Kenneth
AU - Oberdorster, Gunter
AU - Pinkerton, Kent E
AU - Pleus, Richard C.
AU - Shatkin, Jo Anne
AU - Thomas, Russell
AU - Tolaymat, Thabet
AU - Wang, Amy
AU - Wong, Jeffrey
PY - 2013/8/27
Y1 - 2013/8/27
N2 - There has been a conceptual shift in toxicological studies from describing what happens to explaining how the adverse outcome occurs, thereby enabling a deeper and improved understanding of how biomolecular and mechanistic profiling can inform hazard identification and improve risk assessment. Compared to traditional toxicology methods, which have a heavy reliance on animals, new approaches to generate toxicological data are becoming available for the safety assessment of chemicals, including high-throughput and high-content screening (HTS, HCS). With the emergence of nanotechnology, the exponential increase in the total number of engineered nanomaterials (ENMs) in research, development, and commercialization requires a robust scientific approach to screen ENM safety in humans and the environment rapidly and efficiently. Spurred by the developments in chemical testing, a promising new toxicological paradigm for ENMs is to use alternative test strategies (ATS), which reduce reliance on animal testing through the use of in vitro and in silico methods such as HTS, HCS, and computational modeling. Furthermore, this allows for the comparative analysis of large numbers of ENMs simultaneously and for hazard assessment at various stages of the product development process and overall life cycle. Using carbon nanotubes as a case study, a workshop bringing together national and international leaders from government, industry, and academia was convened at the University of California, Los Angeles, to discuss the utility of ATS for decision-making analyses of ENMs. After lively discussions, a short list of generally shared viewpoints on this topic was generated, including a general view that ATS approaches for ENMs can significantly benefit chemical safety analysis.
AB - There has been a conceptual shift in toxicological studies from describing what happens to explaining how the adverse outcome occurs, thereby enabling a deeper and improved understanding of how biomolecular and mechanistic profiling can inform hazard identification and improve risk assessment. Compared to traditional toxicology methods, which have a heavy reliance on animals, new approaches to generate toxicological data are becoming available for the safety assessment of chemicals, including high-throughput and high-content screening (HTS, HCS). With the emergence of nanotechnology, the exponential increase in the total number of engineered nanomaterials (ENMs) in research, development, and commercialization requires a robust scientific approach to screen ENM safety in humans and the environment rapidly and efficiently. Spurred by the developments in chemical testing, a promising new toxicological paradigm for ENMs is to use alternative test strategies (ATS), which reduce reliance on animal testing through the use of in vitro and in silico methods such as HTS, HCS, and computational modeling. Furthermore, this allows for the comparative analysis of large numbers of ENMs simultaneously and for hazard assessment at various stages of the product development process and overall life cycle. Using carbon nanotubes as a case study, a workshop bringing together national and international leaders from government, industry, and academia was convened at the University of California, Los Angeles, to discuss the utility of ATS for decision-making analyses of ENMs. After lively discussions, a short list of generally shared viewpoints on this topic was generated, including a general view that ATS approaches for ENMs can significantly benefit chemical safety analysis.
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U2 - 10.1021/nn4037927
DO - 10.1021/nn4037927
M3 - Article
C2 - 23924032
AN - SCOPUS:84883226901
VL - 7
SP - 6422
EP - 6433
JO - ACS Nano
JF - ACS Nano
SN - 1936-0851
IS - 8
ER -