TY - JOUR
T1 - A more valid measurement of low-density lipoprotein cholesterol in diabetic patients
AU - Hirany, Shaina
AU - Li, Dai
AU - Jialal, Ishwarlal
PY - 1997/1
Y1 - 1997/1
N2 - PURPOSE: This study was conducted to determine if the direct low- density lipoprotein (LDL) cholesterol assay would provide a more valid measure of LDL cholesterol in diabetic patients compared with the Friedewald equation. PATIENTS AND METHODS: Fasting plasma from 148 diabetic patients, 40 with insulin-dependent diabetes (IDDM) and 108 with non-insulin-dependent diabetes (NIDDM) with triglyceride levels <400 mg/dL, were analyzed for LDL cholesterol using the Friedewald equation, the direct LDL assay, and beta- quantification. Forty-six diabetic patients with triglyceride levels ≤400 mg/dL were also studied to determine the validity of the direct LDL cholesterol assay with hypertriglyceridemia. RESULTS: The Friedewald equation and the direct LDL cholesterol assay correlated well with beta-quantification (r = 0.969 and r = 0.971, respectively) for LDL cholesterol determination in diabetic patients. Although the Friedewald equation in comparison with beta- quantification underestimated (8%) LDL cholesterol values in diabetic patients, the direct LDL cholesterol assay had a mean bias of <1%. Also, the underestimation by the Friedewald equation exceeded 10% for the triglyceride subgroup of 200 to 400 mg/dL. Furthermore, the accuracy of the direct LDL cholesterol assay was superior to the Friedewald equation since LDL cholesterol levels determined by the two methods coincided within ± 10% of beta-quantification in 85% and 68% of diabetic patients, respectively (P = 0.0005). Similar results for both the Friedewald equation and the direct LDL cholesterol assay in comparison with beta-quantification were seen when diabetic patients were subgrouped into IDDM and NIDDM. Also, the direct LDL cholesterol assay appeared to provide a reliable estimate in patients with triglycerides ≤400 mg/dL. CONCLUSION: The results of our studies indicate that the direct LDL cholesterol assay is a more reliable and accurate method than the Friedewaid formula for LDL cholesterol determination in diabetic patients and is more rapid and cost effective than the reference method.
AB - PURPOSE: This study was conducted to determine if the direct low- density lipoprotein (LDL) cholesterol assay would provide a more valid measure of LDL cholesterol in diabetic patients compared with the Friedewald equation. PATIENTS AND METHODS: Fasting plasma from 148 diabetic patients, 40 with insulin-dependent diabetes (IDDM) and 108 with non-insulin-dependent diabetes (NIDDM) with triglyceride levels <400 mg/dL, were analyzed for LDL cholesterol using the Friedewald equation, the direct LDL assay, and beta- quantification. Forty-six diabetic patients with triglyceride levels ≤400 mg/dL were also studied to determine the validity of the direct LDL cholesterol assay with hypertriglyceridemia. RESULTS: The Friedewald equation and the direct LDL cholesterol assay correlated well with beta-quantification (r = 0.969 and r = 0.971, respectively) for LDL cholesterol determination in diabetic patients. Although the Friedewald equation in comparison with beta- quantification underestimated (8%) LDL cholesterol values in diabetic patients, the direct LDL cholesterol assay had a mean bias of <1%. Also, the underestimation by the Friedewald equation exceeded 10% for the triglyceride subgroup of 200 to 400 mg/dL. Furthermore, the accuracy of the direct LDL cholesterol assay was superior to the Friedewald equation since LDL cholesterol levels determined by the two methods coincided within ± 10% of beta-quantification in 85% and 68% of diabetic patients, respectively (P = 0.0005). Similar results for both the Friedewald equation and the direct LDL cholesterol assay in comparison with beta-quantification were seen when diabetic patients were subgrouped into IDDM and NIDDM. Also, the direct LDL cholesterol assay appeared to provide a reliable estimate in patients with triglycerides ≤400 mg/dL. CONCLUSION: The results of our studies indicate that the direct LDL cholesterol assay is a more reliable and accurate method than the Friedewaid formula for LDL cholesterol determination in diabetic patients and is more rapid and cost effective than the reference method.
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U2 - 10.1016/S0002-9343(96)00375-0
DO - 10.1016/S0002-9343(96)00375-0
M3 - Article
C2 - 9209200
AN - SCOPUS:0031040327
VL - 102
SP - 48
EP - 53
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 1
ER -