A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurones in Alzheimer's disease

John Morrison, David A. Lewis, Michael J. Campbell, George W. Huntley, Deanna L. Benson, Constantin Bouras

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalBrain Research
Volume416
Issue number2
DOIs
StatePublished - Jul 28 1987
Externally publishedYes

Keywords

  • Dementia
  • Entorchinal cortex
  • Human
  • Neocortex
  • Neurofibrillary tangle
  • Neurofilament
  • Subiculum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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