A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurones in Alzheimer's disease

John Morrison; David A. Lewis; Michael J. Campbell; George W. Huntley; Deanna L. Benson; Constantin Bouras

doi:10.1016/0006-8993(87)90914-0

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurones in Alzheimer's disease

John Morrison, David A. Lewis, Michael J. Campbell, George W. Huntley, Deanna L. Benson, Constantin Bouras

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.

Original language	English (US)
Pages (from-to)	331-336
Number of pages	6
Journal	Brain Research
Volume	416
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90914-0
State	Published - Jul 28 1987
Externally published	Yes

Keywords

Dementia
Entorchinal cortex
Human
Neocortex
Neurofibrillary tangle
Neurofilament
Subiculum

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90914-0

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A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurones in Alzheimer's disease. / Morrison, John; Lewis, David A.; Campbell, Michael J.; Huntley, George W.; Benson, Deanna L.; Bouras, Constantin.

In: Brain Research, Vol. 416, No. 2, 28.07.1987, p. 331-336.

Research output: Contribution to journal › Article › peer-review

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