Abstract
Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.
Original language | English (US) |
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Pages (from-to) | 331-336 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 416 |
Issue number | 2 |
DOIs | |
State | Published - Jul 28 1987 |
Externally published | Yes |
Keywords
- Dementia
- Entorchinal cortex
- Human
- Neocortex
- Neurofibrillary tangle
- Neurofilament
- Subiculum
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology