Abstract
Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 331-336 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 416 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 28 1987 |
| Externally published | Yes |
Keywords
- Dementia
- Entorchinal cortex
- Human
- Neocortex
- Neurofibrillary tangle
- Neurofilament
- Subiculum
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Cite this
Morrison, J., Lewis, D. A., Campbell, M. J., Huntley, G. W., Benson, D. L., & Bouras, C. (1987). A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurones in Alzheimer's disease. Brain Research, 416(2), 331-336. https://doi.org/10.1016/0006-8993(87)90914-0