Abstract
A broad spectrum monoamine oxidase inhibitor, tranylcypromine sulfate (Parnate) was tested in a new hamster separation model of depression. In this paradigm, male dwarf hamsters show increases in body weight, decreases in exploratory behaviors, and decreases in social interactions, when separated from female mates. Tranylcypromine (10 mg/kg s.c. daily for 14 days) effectively reduced body weight, increased exploration, and increased social interaction, in the separated males. Subsequent treatment with saline restored the separation-induced changes in body weight, exploratory behaviors, and other social behaviors. The 'separation syndrome' in dwarf hamsters appears to be completely reversed by at least one antidepressant treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 129-133 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 112 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 28 1985 |
| Externally published | Yes |
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Keywords
- Depression
- Dwarf hamster
- Monoamine oxidase
- Separation
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
A monoamine oxidase inhibitor reverses the 'separation syndrome' in a new hamster separation model of depression. / Crawley, Jacqueline.
In: European Journal of Pharmacology, Vol. 112, No. 1, 28.05.1985, p. 129-133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A monoamine oxidase inhibitor reverses the 'separation syndrome' in a new hamster separation model of depression
AU - Crawley, Jacqueline
PY - 1985/5/28
Y1 - 1985/5/28
N2 - A broad spectrum monoamine oxidase inhibitor, tranylcypromine sulfate (Parnate) was tested in a new hamster separation model of depression. In this paradigm, male dwarf hamsters show increases in body weight, decreases in exploratory behaviors, and decreases in social interactions, when separated from female mates. Tranylcypromine (10 mg/kg s.c. daily for 14 days) effectively reduced body weight, increased exploration, and increased social interaction, in the separated males. Subsequent treatment with saline restored the separation-induced changes in body weight, exploratory behaviors, and other social behaviors. The 'separation syndrome' in dwarf hamsters appears to be completely reversed by at least one antidepressant treatment.
AB - A broad spectrum monoamine oxidase inhibitor, tranylcypromine sulfate (Parnate) was tested in a new hamster separation model of depression. In this paradigm, male dwarf hamsters show increases in body weight, decreases in exploratory behaviors, and decreases in social interactions, when separated from female mates. Tranylcypromine (10 mg/kg s.c. daily for 14 days) effectively reduced body weight, increased exploration, and increased social interaction, in the separated males. Subsequent treatment with saline restored the separation-induced changes in body weight, exploratory behaviors, and other social behaviors. The 'separation syndrome' in dwarf hamsters appears to be completely reversed by at least one antidepressant treatment.
KW - Depression
KW - Dwarf hamster
KW - Monoamine oxidase
KW - Separation
UR - http://www.scopus.com/inward/record.url?scp=0021815497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021815497&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(85)90250-X
DO - 10.1016/0014-2999(85)90250-X
M3 - Article
C2 - 4040468
AN - SCOPUS:0021815497
VL - 112
SP - 129
EP - 133
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -