A monoamine oxidase inhibitor reverses the 'separation syndrome' in a new hamster separation model of depression

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12 Citations (Scopus)

Abstract

A broad spectrum monoamine oxidase inhibitor, tranylcypromine sulfate (Parnate) was tested in a new hamster separation model of depression. In this paradigm, male dwarf hamsters show increases in body weight, decreases in exploratory behaviors, and decreases in social interactions, when separated from female mates. Tranylcypromine (10 mg/kg s.c. daily for 14 days) effectively reduced body weight, increased exploration, and increased social interaction, in the separated males. Subsequent treatment with saline restored the separation-induced changes in body weight, exploratory behaviors, and other social behaviors. The 'separation syndrome' in dwarf hamsters appears to be completely reversed by at least one antidepressant treatment.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalEuropean Journal of Pharmacology
Volume112
Issue number1
DOIs
StatePublished - May 28 1985
Externally publishedYes

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Tranylcypromine
Monoamine Oxidase Inhibitors
Cricetinae
Exploratory Behavior
Depression
Interpersonal Relations
Body Weight
Body Weight Changes
Social Behavior
Antidepressive Agents
Therapeutics

Keywords

  • Depression
  • Dwarf hamster
  • Monoamine oxidase
  • Separation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

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abstract = "A broad spectrum monoamine oxidase inhibitor, tranylcypromine sulfate (Parnate) was tested in a new hamster separation model of depression. In this paradigm, male dwarf hamsters show increases in body weight, decreases in exploratory behaviors, and decreases in social interactions, when separated from female mates. Tranylcypromine (10 mg/kg s.c. daily for 14 days) effectively reduced body weight, increased exploration, and increased social interaction, in the separated males. Subsequent treatment with saline restored the separation-induced changes in body weight, exploratory behaviors, and other social behaviors. The 'separation syndrome' in dwarf hamsters appears to be completely reversed by at least one antidepressant treatment.",
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