A molecular marker for fibrotic collagen in lungs of infants with respiratory distress syndrome

Karen M. Reiser, Jerold A Last

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Lung samples from four infants who died of respiratory complications of prematurity (Infant Respiratory Distress Syndrome, IRDS) were analyzed for their content of various collagen crosslink amino acids by newly developed techniques of high-performance liquid chromatography. Comparable analyses were performed with tissue from stillborn infants with apparently normal lungs (control group) and from adults without apparent lung disease. We observed increased amounts of the difunctional crosslink dihydroxylysinonorleucine (DHLNL) in the IRDS lungs. Gestational age seemed to be the most important determinant of total lung content of the trifunctional crosslink hydroxypyridinium (OHP). Term infants had about one-third of the OHP content in their lung collagen as was found in the adult lungs. These observations suggest that there are important changes in the molecular structure of collagen in a human fibrotic lung disease, changes that are paralleled in various animal models of experimental pulmonary fibrosis, and in various human diseases involving abnormalities of skin or bone collagen metabolism.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalBiochemical Medicine and Metabolic Biology
Volume37
Issue number1
DOIs
StatePublished - 1987

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Newborn Respiratory Distress Syndrome
Collagen
Lung
Pulmonary diseases
Lung Diseases
High performance liquid chromatography
Skin Abnormalities
Metabolism
Molecular structure
Skin
Bone
Animals
Pulmonary Fibrosis
Tissue
Molecular Structure
Amino Acids
Gestational Age
Animal Models
High Pressure Liquid Chromatography
Bone and Bones

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

A molecular marker for fibrotic collagen in lungs of infants with respiratory distress syndrome. / Reiser, Karen M.; Last, Jerold A.

In: Biochemical Medicine and Metabolic Biology, Vol. 37, No. 1, 1987, p. 16-21.

Research output: Contribution to journalArticle

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