Abstract
The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochondrial genetic variation. Recently, a gene involved has been identified as the mitochondrial small ribosomal RNA gene, consistent with the known mechanism of aminoglycoside action against bacteria. We used the existing data as a basis for our hypothesis of a molecular and cellular model for aminoglycoside ototoxicity that is described in this paper.
Original language | English (US) |
---|---|
Pages (from-to) | 27-30 |
Number of pages | 4 |
Journal | Hearing Research |
Volume | 78 |
Issue number | 1 |
DOIs | |
State | Published - 1994 |
Externally published | Yes |
Keywords
- Aminoglycoside
- Hair cells
- Mitochondria
- Molecular mechanism
- Ototoxicit
- Ribosome
ASJC Scopus subject areas
- Sensory Systems