A molecular and cellular hypothesis for aminoglycoside-induced deafness

Gino A Cortopassi, Tim Hutchin

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochondrial genetic variation. Recently, a gene involved has been identified as the mitochondrial small ribosomal RNA gene, consistent with the known mechanism of aminoglycoside action against bacteria. We used the existing data as a basis for our hypothesis of a molecular and cellular model for aminoglycoside ototoxicity that is described in this paper.

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalHearing Research
Volume78
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Aminoglycoside
  • Hair cells
  • Mitochondria
  • Molecular mechanism
  • Ototoxicit
  • Ribosome

ASJC Scopus subject areas

  • Sensory Systems

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