Abstract
The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochondrial genetic variation. Recently, a gene involved has been identified as the mitochondrial small ribosomal RNA gene, consistent with the known mechanism of aminoglycoside action against bacteria. We used the existing data as a basis for our hypothesis of a molecular and cellular model for aminoglycoside ototoxicity that is described in this paper.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-30 |
| Number of pages | 4 |
| Journal | Hearing Research |
| Volume | 78 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
Keywords
- Aminoglycoside
- Hair cells
- Mitochondria
- Molecular mechanism
- Ototoxicit
- Ribosome
ASJC Scopus subject areas
- Sensory Systems
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Cite this
Cortopassi, G. A., & Hutchin, T. (1994). A molecular and cellular hypothesis for aminoglycoside-induced deafness. Hearing Research, 78(1), 27-30. https://doi.org/10.1016/0378-5955(94)90040-X