Abstract
The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochondrial genetic variation. Recently, a gene involved has been identified as the mitochondrial small ribosomal RNA gene, consistent with the known mechanism of aminoglycoside action against bacteria. We used the existing data as a basis for our hypothesis of a molecular and cellular model for aminoglycoside ototoxicity that is described in this paper.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-30 |
| Number of pages | 4 |
| Journal | Hearing Research |
| Volume | 78 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- Aminoglycoside
- Hair cells
- Mitochondria
- Molecular mechanism
- Ototoxicit
- Ribosome
ASJC Scopus subject areas
- Sensory Systems
Cite this
A molecular and cellular hypothesis for aminoglycoside-induced deafness. / Cortopassi, Gino A; Hutchin, Tim.
In: Hearing Research, Vol. 78, No. 1, 1994, p. 27-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A molecular and cellular hypothesis for aminoglycoside-induced deafness
AU - Cortopassi, Gino A
AU - Hutchin, Tim
PY - 1994
Y1 - 1994
N2 - The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochondrial genetic variation. Recently, a gene involved has been identified as the mitochondrial small ribosomal RNA gene, consistent with the known mechanism of aminoglycoside action against bacteria. We used the existing data as a basis for our hypothesis of a molecular and cellular model for aminoglycoside ototoxicity that is described in this paper.
AB - The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochondrial genetic variation. Recently, a gene involved has been identified as the mitochondrial small ribosomal RNA gene, consistent with the known mechanism of aminoglycoside action against bacteria. We used the existing data as a basis for our hypothesis of a molecular and cellular model for aminoglycoside ototoxicity that is described in this paper.
KW - Aminoglycoside
KW - Hair cells
KW - Mitochondria
KW - Molecular mechanism
KW - Ototoxicit
KW - Ribosome
UR - http://www.scopus.com/inward/record.url?scp=0028022596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028022596&partnerID=8YFLogxK
U2 - 10.1016/0378-5955(94)90040-X
DO - 10.1016/0378-5955(94)90040-X
M3 - Article
C2 - 7961174
AN - SCOPUS:0028022596
VL - 78
SP - 27
EP - 30
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1
ER -