A Modern Reaffirmation of Surgery as the Optimal Treatment for Solitary Fibrous Tumors of the Pleura

Mimi J. Yao, Li Ding, Scott M. Atay, Omar Toubat, Peggy Ebner, Elizabeth David, P. Michael McFadden, Anthony W. Kim

Research output: Contribution to journalArticle

Abstract

Background: The objective of this study was to identify the most effective treatment for survival in patients with solitary fibrous tumors of the pleura (SFTP). Methods: The National Cancer Database was queried for patients with malignant SFTPs. Patients were divided into two groups, those who had surgical treatment and those who did not. The primary outcome was 5-year overall survival, which was assessed by the Kaplan-Meier method and compared using the log rank test. Results: There were 204 patients with SFTPs identified between 2004 and 2014. Of those, 65% of patients (133) had surgical intervention, whereas 18% (37) had no surgical intervention, and 17% (34) had unknown treatment information. Among patients who underwent resection, 42% (56) had sublobar resections, 45% (60) had lobectomies, and 13% (17) had pneumonectomies. The overall 5-year survival for SFTP patients was 56%. Patients who had surgical intervention had a relative survival of 64%, and patients with no surgical intervention had 22% (p < 0.001). There was no difference in 5-year survival among patients who had sublobar resections compared with patients who had greater anatomic resections (65% versus 64%, p = 0.823). Conclusions: Patients with SFTP who were managed with surgical intervention have better overall survival than patients who are not managed with surgery. Furthermore, similar 5-year survival for sublobar resections compared with greater anatomic resections suggested that the former, when possible, is sufficient.

Original languageEnglish (US)
JournalAnnals of Thoracic Surgery
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

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Pleural Solitary Fibrous Tumor
Survival
Therapeutics
Pneumonectomy

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

A Modern Reaffirmation of Surgery as the Optimal Treatment for Solitary Fibrous Tumors of the Pleura. / Yao, Mimi J.; Ding, Li; Atay, Scott M.; Toubat, Omar; Ebner, Peggy; David, Elizabeth; McFadden, P. Michael; Kim, Anthony W.

In: Annals of Thoracic Surgery, 01.01.2019.

Research output: Contribution to journalArticle

Yao, Mimi J. ; Ding, Li ; Atay, Scott M. ; Toubat, Omar ; Ebner, Peggy ; David, Elizabeth ; McFadden, P. Michael ; Kim, Anthony W. / A Modern Reaffirmation of Surgery as the Optimal Treatment for Solitary Fibrous Tumors of the Pleura. In: Annals of Thoracic Surgery. 2019.
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abstract = "Background: The objective of this study was to identify the most effective treatment for survival in patients with solitary fibrous tumors of the pleura (SFTP). Methods: The National Cancer Database was queried for patients with malignant SFTPs. Patients were divided into two groups, those who had surgical treatment and those who did not. The primary outcome was 5-year overall survival, which was assessed by the Kaplan-Meier method and compared using the log rank test. Results: There were 204 patients with SFTPs identified between 2004 and 2014. Of those, 65{\%} of patients (133) had surgical intervention, whereas 18{\%} (37) had no surgical intervention, and 17{\%} (34) had unknown treatment information. Among patients who underwent resection, 42{\%} (56) had sublobar resections, 45{\%} (60) had lobectomies, and 13{\%} (17) had pneumonectomies. The overall 5-year survival for SFTP patients was 56{\%}. Patients who had surgical intervention had a relative survival of 64{\%}, and patients with no surgical intervention had 22{\%} (p < 0.001). There was no difference in 5-year survival among patients who had sublobar resections compared with patients who had greater anatomic resections (65{\%} versus 64{\%}, p = 0.823). Conclusions: Patients with SFTP who were managed with surgical intervention have better overall survival than patients who are not managed with surgery. Furthermore, similar 5-year survival for sublobar resections compared with greater anatomic resections suggested that the former, when possible, is sufficient.",
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AU - Toubat, Omar

AU - Ebner, Peggy

AU - David, Elizabeth

AU - McFadden, P. Michael

AU - Kim, Anthony W.

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