A model of Coccidioidal meningoencephalitis and cerebrospinal vasculitis in the rabbit

P. L. Williams, R. A. Sobel, K. N. Sorensen, K. V. Clemons, L. M. Shuer, S. S. Royaltey, Y. Yao, D. Pappagianis, J. E. Lutz, C. Reed, M. E. River, B. Lee C, S. U. Bhatti, D. A. Stevens

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Coccidioidal meningitis is a devastating complication of disseminated coccidioidomycosis. An animal model of this infection could enhance understanding of the pathogenesis of the disease and lead to improvements in therapy. A rabbit model of central nervous system infection simulating human disease was established using a blind cisternal tap technique to inoculate 4 x 103-1 x 106 arthroconidia of Coccidioides immitis into the cisterna magna. Systemic, neurologic, and histopathologic findings of meningitis were observed in all rabbits, but an inoculum of 2 x 104 arthroconidia produced a chronic illness in which meningeal endarteritis obliterans was consistently observed. serial sampling of cerebrospinal fluid demonstrated an inflammatory response. Growth of C. immitis was demonstrated by quantitative fungal culture from brains and proximal spinal cords.

Original languageEnglish (US)
Pages (from-to)1217-1221
Number of pages5
JournalJournal of Infectious Diseases
Volume178
Issue number4
StatePublished - 1998

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Williams, P. L., Sobel, R. A., Sorensen, K. N., Clemons, K. V., Shuer, L. M., Royaltey, S. S., Yao, Y., Pappagianis, D., Lutz, J. E., Reed, C., River, M. E., Lee C, B., Bhatti, S. U., & Stevens, D. A. (1998). A model of Coccidioidal meningoencephalitis and cerebrospinal vasculitis in the rabbit. Journal of Infectious Diseases, 178(4), 1217-1221.