A mild, catalyst-free synthesis of 2-aminopyridines

Bhaskar Poola, Wonken Choung, Michael H. Nantz

Research output: Contribution to journal › Article

13 Citations (Scopus)

Abstract

Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

Original languageEnglish (US)
Pages (from-to)10798-10801
Number of pages4
JournalTetrahedron
Volume64
Issue number48
DOIs
StatePublished - Nov 24 2008
Externally publishedYes

Fingerprint

Ethylene Dibromide
Alkylation
Dimethyl Sulfoxide
Amines
Salts
Catalysts
2-thiopyridine
alpha-aminopyridine

Keywords

  • Aminopyridine
  • Heteroaryl amine
  • N-Alkyl pyridinium
  • Thiazolopyridinium

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Poola, B., Choung, W., & Nantz, M. H. (2008). A mild, catalyst-free synthesis of 2-aminopyridines. Tetrahedron, 64(48), 10798-10801. https://doi.org/10.1016/j.tet.2008.09.010

A mild, catalyst-free synthesis of 2-aminopyridines. / Poola, Bhaskar; Choung, Wonken; Nantz, Michael H.

In: Tetrahedron, Vol. 64, No. 48, 24.11.2008, p. 10798-10801.

Research output: Contribution to journal › Article

Poola, B, Choung, W & Nantz, MH 2008, 'A mild, catalyst-free synthesis of 2-aminopyridines', Tetrahedron, vol. 64, no. 48, pp. 10798-10801. https://doi.org/10.1016/j.tet.2008.09.010
Poola B, Choung W, Nantz MH. A mild, catalyst-free synthesis of 2-aminopyridines. Tetrahedron. 2008 Nov 24;64(48):10798-10801. https://doi.org/10.1016/j.tet.2008.09.010
Poola, Bhaskar ; Choung, Wonken ; Nantz, Michael H. / A mild, catalyst-free synthesis of 2-aminopyridines. In: Tetrahedron. 2008 ; Vol. 64, No. 48. pp. 10798-10801.
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