Abstract
Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10798-10801 |
| Number of pages | 4 |
| Journal | Tetrahedron |
| Volume | 64 |
| Issue number | 48 |
| DOIs | |
| State | Published - Nov 24 2008 |
| Externally published | Yes |
Keywords
- Aminopyridine
- Heteroaryl amine
- N-Alkyl pyridinium
- Thiazolopyridinium
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Cite this
Poola, B., Choung, W., & Nantz, M. H. (2008). A mild, catalyst-free synthesis of 2-aminopyridines. Tetrahedron, 64(48), 10798-10801. https://doi.org/10.1016/j.tet.2008.09.010