A mild, catalyst-free synthesis of 2-aminopyridines

Bhaskar Poola, Wonken Choung, Michael H. Nantz

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

Original languageEnglish (US)
Pages (from-to)10798-10801
Number of pages4
JournalTetrahedron
Volume64
Issue number48
DOIs
StatePublished - Nov 24 2008
Externally publishedYes

Keywords

  • Aminopyridine
  • Heteroaryl amine
  • N-Alkyl pyridinium
  • Thiazolopyridinium

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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  • Cite this

    Poola, B., Choung, W., & Nantz, M. H. (2008). A mild, catalyst-free synthesis of 2-aminopyridines. Tetrahedron, 64(48), 10798-10801. https://doi.org/10.1016/j.tet.2008.09.010