A mild, catalyst-free synthesis of 2-aminopyridines

Bhaskar Poola, Wonken Choung, Michael H. Nantz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

Original languageEnglish (US)
Pages (from-to)10798-10801
Number of pages4
Issue number48
StatePublished - Nov 24 2008
Externally publishedYes


  • Aminopyridine
  • Heteroaryl amine
  • N-Alkyl pyridinium
  • Thiazolopyridinium

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Fingerprint Dive into the research topics of 'A mild, catalyst-free synthesis of 2-aminopyridines'. Together they form a unique fingerprint.

Cite this