A mild, catalyst-free synthesis of 2-aminopyridines

Bhaskar Poola; Wonken Choung; Michael H. Nantz

doi:10.1016/j.tet.2008.09.010

A mild, catalyst-free synthesis of 2-aminopyridines

Bhaskar Poola, Wonken Choung, Michael H. Nantz

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

Original language	English (US)
Pages (from-to)	10798-10801
Number of pages	4
Journal	Tetrahedron
Volume	64
Issue number	48
DOIs	https://doi.org/10.1016/j.tet.2008.09.010
State	Published - Nov 24 2008
Externally published	Yes

Keywords

Aminopyridine
Heteroaryl amine
N-Alkyl pyridinium
Thiazolopyridinium

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

Access to Document

10.1016/j.tet.2008.09.010

Fingerprint Dive into the research topics of 'A mild, catalyst-free synthesis of 2-aminopyridines'. Together they form a unique fingerprint.

Cite this

@article{0ea705e611b74d558918e50cc2bd4841,

title = "A mild, catalyst-free synthesis of 2-aminopyridines",

abstract = "Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.",

keywords = "Aminopyridine, Heteroaryl amine, N-Alkyl pyridinium, Thiazolopyridinium",

author = "Bhaskar Poola and Wonken Choung and Nantz, {Michael H.}",

year = "2008",

month = nov,

day = "24",

doi = "10.1016/j.tet.2008.09.010",

language = "English (US)",

volume = "64",

pages = "10798--10801",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

number = "48",

}

TY - JOUR

T1 - A mild, catalyst-free synthesis of 2-aminopyridines

AU - Poola, Bhaskar

AU - Choung, Wonken

AU - Nantz, Michael H.

PY - 2008/11/24

Y1 - 2008/11/24

N2 - Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

AB - Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

KW - Aminopyridine

KW - Heteroaryl amine

KW - N-Alkyl pyridinium

KW - Thiazolopyridinium

UR - http://www.scopus.com/inward/record.url?scp=53449089791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53449089791&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2008.09.010

DO - 10.1016/j.tet.2008.09.010

M3 - Article

AN - SCOPUS:53449089791

VL - 64

SP - 10798

EP - 10801

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 48

ER -