Abstract
Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.
Original language | English (US) |
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Pages (from-to) | 10798-10801 |
Number of pages | 4 |
Journal | Tetrahedron |
Volume | 64 |
Issue number | 48 |
DOIs | |
State | Published - Nov 24 2008 |
Externally published | Yes |
Keywords
- Aminopyridine
- Heteroaryl amine
- N-Alkyl pyridinium
- Thiazolopyridinium
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery