A microPET/CT system for invivo small animal imaging

H. Liang, Y. Yang, K. Yang, Y. Wu, John M Boone, Simon R Cherry

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A microCT scanner was designed, fabricated and integrated with a previously reported microPET II scanner (Tai et al 2003 Phys. Med. Biol. 48 1519, Yang et al 2004 Phys. Med. Biol. 49 2527), forming a dual modality system for in vivo anatomic and molecular imaging of the mouse. The system was designed to achieve high-spatial-resolution and high-sensitivity PET images with adequate CT image quality for anatomic localization and attenuation correction with low x-ray dose. The system also has relatively high throughput for screening, and a flexible gantry and user interface. X-rays were produced by a 50 kVp, 1.5 mA fixed tungsten anode tube, with a focal spot size of 70 μm. The detector was a 5 × 5 cm2 photodiode detector incorporating 48 μm pixels on a CMOS array and a fast gadolinium oxysulfide (GOS) intensifying screen. The microCT system has a flexible C-arm gantry design with adjustable detector positioning, which acquires CT projection images around the common microPET/CT bed. The design and the initial characterization of the microCT system is described, and images of the first mouse scans with microPET/CT scanning protocols are shown.

Original languageEnglish (US)
Article number015
Pages (from-to)3881-3894
Number of pages14
JournalPhysics in Medicine and Biology
Volume52
Issue number13
DOIs
StatePublished - Jul 7 2007

Fingerprint

X-Ray Microtomography
animals
Animals
Detectors
Imaging techniques
gantry cranes
X-Rays
scanners
mice
Molecular imaging
X rays
detectors
Tungsten
tube anodes
Molecular Imaging
Gadolinium
Photodiodes
Image quality
User interfaces
Dosimetry

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A microPET/CT system for invivo small animal imaging. / Liang, H.; Yang, Y.; Yang, K.; Wu, Y.; Boone, John M; Cherry, Simon R.

In: Physics in Medicine and Biology, Vol. 52, No. 13, 015, 07.07.2007, p. 3881-3894.

Research output: Contribution to journalArticle

Liang, H. ; Yang, Y. ; Yang, K. ; Wu, Y. ; Boone, John M ; Cherry, Simon R. / A microPET/CT system for invivo small animal imaging. In: Physics in Medicine and Biology. 2007 ; Vol. 52, No. 13. pp. 3881-3894.
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