A microfabricated preconcentrating device for exhaled breath analysis

M. Li, S. Biswas, M. H. Nantz, R. M. Higashi, X. A. Fu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.

Original languageEnglish (US)
Title of host publication2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages1148-1151
Number of pages4
DOIs
StatePublished - 2011
Externally publishedYes
Event2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China
Duration: Jun 5 2011Jun 9 2011

Other

Other2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
CountryChina
CityBeijing
Period6/5/116/9/11

Keywords

  • Breath analysis
  • FT-ICR-MS
  • Ketones and aldehyde
  • Microreactor
  • Preconcentrator

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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  • Cite this

    Li, M., Biswas, S., Nantz, M. H., Higashi, R. M., & Fu, X. A. (2011). A microfabricated preconcentrating device for exhaled breath analysis. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 1148-1151). [5969255] https://doi.org/10.1109/TRANSDUCERS.2011.5969255