Abstract
Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.
| Original language | English (US) |
|---|---|
| Title of host publication | 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 |
| Pages | 1148-1151 |
| Number of pages | 4 |
| DOIs | |
| State | Published - 2011 |
| Externally published | Yes |
| Event | 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China Duration: Jun 5 2011 → Jun 9 2011 |
Other
| Other | 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 |
|---|---|
| Country | China |
| City | Beijing |
| Period | 6/5/11 → 6/9/11 |
Fingerprint
Keywords
- Breath analysis
- FT-ICR-MS
- Ketones and aldehyde
- Microreactor
- Preconcentrator
ASJC Scopus subject areas
- Hardware and Architecture
- Electrical and Electronic Engineering
Cite this
A microfabricated preconcentrating device for exhaled breath analysis. / Li, M.; Biswas, S.; Nantz, M. H.; Higashi, R. M.; Fu, X. A.
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 1148-1151 5969255.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - A microfabricated preconcentrating device for exhaled breath analysis
AU - Li, M.
AU - Biswas, S.
AU - Nantz, M. H.
AU - Higashi, R. M.
AU - Fu, X. A.
PY - 2011
Y1 - 2011
N2 - Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.
AB - Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.
KW - Breath analysis
KW - FT-ICR-MS
KW - Ketones and aldehyde
KW - Microreactor
KW - Preconcentrator
UR - http://www.scopus.com/inward/record.url?scp=80052107922&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052107922&partnerID=8YFLogxK
U2 - 10.1109/TRANSDUCERS.2011.5969255
DO - 10.1109/TRANSDUCERS.2011.5969255
M3 - Conference contribution
AN - SCOPUS:80052107922
SN - 9781457701573
SP - 1148
EP - 1151
BT - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
ER -