A microfabricated preconcentrating device for exhaled breath analysis

M. Li; S. Biswas; M. H. Nantz; R. M. Higashi; X. A. Fu

doi:10.1109/TRANSDUCERS.2011.5969255

A microfabricated preconcentrating device for exhaled breath analysis

M. Li, S. Biswas, M. H. Nantz, R. M. Higashi, X. A. Fu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.

Original language	English (US)
Title of host publication	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages	1148-1151
Number of pages	4
DOIs	https://doi.org/10.1109/TRANSDUCERS.2011.5969255
State	Published - 2011
Externally published	Yes
Event	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China Duration: Jun 5 2011 → Jun 9 2011

Other

Other	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Country	China
City	Beijing
Period	6/5/11 → 6/9/11

Keywords

Breath analysis
FT-ICR-MS
Ketones and aldehyde
Microreactor
Preconcentrator

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering

Access to Document

10.1109/TRANSDUCERS.2011.5969255

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Cite this

Li, M., Biswas, S., Nantz, M. H., Higashi, R. M., & Fu, X. A. (2011). A microfabricated preconcentrating device for exhaled breath analysis. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 1148-1151). [5969255] https://doi.org/10.1109/TRANSDUCERS.2011.5969255

Li, M, Biswas, S, Nantz, MH, Higashi, RM & Fu, XA 2011, A microfabricated preconcentrating device for exhaled breath analysis. in 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11., 5969255, pp. 1148-1151, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, Beijing, China, 6/5/11. https://doi.org/10.1109/TRANSDUCERS.2011.5969255

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title = "A microfabricated preconcentrating device for exhaled breath analysis",

abstract = "Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.",

keywords = "Breath analysis, FT-ICR-MS, Ketones and aldehyde, Microreactor, Preconcentrator",

author = "M. Li and S. Biswas and Nantz, {M. H.} and Higashi, {R. M.} and Fu, {X. A.}",

year = "2011",

doi = "10.1109/TRANSDUCERS.2011.5969255",

language = "English (US)",

isbn = "9781457701573",

pages = "1148--1151",

booktitle = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

note = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 ; Conference date: 05-06-2011 Through 09-06-2011",

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AU - Li, M.

AU - Biswas, S.

AU - Nantz, M. H.

AU - Higashi, R. M.

AU - Fu, X. A.

PY - 2011

Y1 - 2011

N2 - Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.

AB - Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.

KW - Breath analysis

KW - FT-ICR-MS

KW - Ketones and aldehyde

KW - Microreactor

KW - Preconcentrator

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