A Microcantilever-Based Pathogen Detector

Brandon L. Weeks, J. Camarero, Aleksandr Noy, A. E. Miller, L. Stanker, J. J. De Yoreo

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The ability to detect small amounts of materials, especially bacterial organisms, is important for medical diagnostics and national security issues. Engineered micromechanical systems provide one approach for constructing multifunctional, highly sensitive, real-time, immunospecific biological detectors. We present qualitative detection of specific Salmonella enterica strains using a functionalized silicon nitride microcantilever. Detection is achieved due to a change in the surface stress on the cantilever surface in situ upon binding of a small number of bacteria. Scanning electron micrographs indicate that less than 25 adsorbed bacteria are required for detection.

Original languageEnglish (US)
Pages (from-to)297-299
Number of pages3
JournalScanning
Volume25
Issue number6
StatePublished - Nov 2003
Externally publishedYes

Keywords

  • Biosensor
  • Cantilever
  • Immunosensor
  • Microfabrication
  • Surface functionalization

ASJC Scopus subject areas

  • Instrumentation

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  • Cite this

    Weeks, B. L., Camarero, J., Noy, A., Miller, A. E., Stanker, L., & De Yoreo, J. J. (2003). A Microcantilever-Based Pathogen Detector. Scanning, 25(6), 297-299.