A lytic viral long noncoding RNA modulates the function of a latent protein

Mel Campbell, Kevin Y. Kim, Pei Ching Chang, Steve Huerta, Bogdan Shevchenko, Don Hong Wang, Chie Izumiya, Hsing Jien Kung, Yoshihiro Izumiya

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.

Original languageEnglish (US)
Pages (from-to)1843-1848
Number of pages6
JournalJournal of Virology
Volume88
Issue number3
DOIs
StatePublished - Feb 2014

ASJC Scopus subject areas

  • Immunology
  • Virology

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