A locus on the X Chromosome is linked to body length in mice

A. V. Lembertas, J. S. Fisler, Craig H Warden, P. Z. Wen, Y. R. Xia, A. J. Lusis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Linkage between body length (anus to nose (AN) length) and three markers on the mouse X Chromosome was found in an interspecific backcross ((C57BL/6J × Mus spretus) F1 × C57BL/6J), designated BSB. A cross of 409 mice were scored for 148 genetic markers distributed on all chromosomes except the Y Chromosome. Statistical analysis revealed highly significant linkage (LOD score 5.5) between body length and a locus in the middle portion of the X Chromosome, the nearest markers being the microsatellite marker DXMit73 and a farnesyl pyrophosphate locus (Fpsl9) 3.1 cM proximal to DXMit73. The locus explains 10% of the variance in AN length and affects both males and females to about the same extent.

Original languageEnglish (US)
Pages (from-to)171-173
Number of pages3
JournalMammalian Genome
Volume7
Issue number3
StatePublished - 1996

ASJC Scopus subject areas

  • Genetics

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