A little nip and tuck: Axon refinement during development and axonal injury

Lawrence K. Low, Hwai-Jong Cheng

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

While building the nervous system, regions of some developing axons are eliminated; this can also happen as a result of axonal injury. During development, many axon branches that are formed in excess of an organism's needs are fated for removal in a process called axon pruning. By contrast, when axons are injured the axon segment distal to the injury site is compartmentalized and eliminated. In both cases, the end result is similar - a region of an axon is selected for removal. Recent evidence suggests that there are some similarities in the cellular and molecular mechanisms that regulate axon elimination in development and during axonal injury.

Original languageEnglish (US)
Pages (from-to)549-556
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume15
Issue number5
DOIs
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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