A linear B-spline threshold dose-response model with dose-specific response variation applied to developmental toxicity studies

Chin-Shang Li, Daniel L. Hunt

Research output: Contribution to journalArticle

Abstract

A linear B-spline function was modified to model dose-specific response variation in developmental toxicity studies. In this new model, response variation is assumed to differ across dose groups. The model was applied to a developmental toxicity study and proved to be significant over the previous model of singular response variation.

Original languageEnglish (US)
Pages (from-to)571-582
Number of pages12
JournalJournal of Modern Applied Statistical Methods
Volume8
Issue number2
StatePublished - Nov 2009

Keywords

  • Developmental toxicity study
  • Dose-response
  • Interior knot
  • Linear B-spline
  • Response variation
  • Threshold

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Statistics and Probability

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