Abstract
A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-18 |
| Number of pages | 8 |
| Journal | Biomaterials |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2003 |
| Externally published | Yes |
Fingerprint
Keywords
- Hydrogel
- In situ cross-linking
- Poly(ethylene glycol)
- Protein drug delivery
- Thiol-containing copolymer
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
Cite this
A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer : A new biomaterial for protein drug delivery. / Qiu, Bo; Stefanos, Simon; Ma, Jianglin; Lalloo, Anita; Perry, Barbara A.; Leibowitz, Michael J; Sinko, Patrick J.; Stein, Stanley.
In: Biomaterials, Vol. 24, No. 1, 01.2003, p. 11-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer
T2 - A new biomaterial for protein drug delivery
AU - Qiu, Bo
AU - Stefanos, Simon
AU - Ma, Jianglin
AU - Lalloo, Anita
AU - Perry, Barbara A.
AU - Leibowitz, Michael J
AU - Sinko, Patrick J.
AU - Stein, Stanley
PY - 2003/1
Y1 - 2003/1
N2 - A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.
AB - A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.
KW - Hydrogel
KW - In situ cross-linking
KW - Poly(ethylene glycol)
KW - Protein drug delivery
KW - Thiol-containing copolymer
UR - http://www.scopus.com/inward/record.url?scp=0037209905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037209905&partnerID=8YFLogxK
U2 - 10.1016/S0142-9612(02)00227-2
DO - 10.1016/S0142-9612(02)00227-2
M3 - Article
C2 - 12417173
AN - SCOPUS:0037209905
VL - 24
SP - 11
EP - 18
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 1
ER -