A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: A new biomaterial for protein drug delivery

Bo Qiu, Simon Stefanos, Jianglin Ma, Anita Lalloo, Barbara A. Perry, Michael J Leibowitz, Patrick J. Sinko, Stanley Stein

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalBiomaterials
Volume24
Issue number1
DOIs
StatePublished - Jan 2003
Externally publishedYes

Fingerprint

Ethylene Glycol
Hydrogel
Biocompatible Materials
Drug delivery
Sulfhydryl Compounds
Biomaterials
Hydrogels
Polyethylene glycols
Chemokine CCL5
Copolymers
Proteins
Pharmaceutical Preparations
Bovine Serum Albumin
Erythropoietin
Bioactivity
Fluorescein
Organic solvents
Polymers
Animals
Derivatives

Keywords

  • Hydrogel
  • In situ cross-linking
  • Poly(ethylene glycol)
  • Protein drug delivery
  • Thiol-containing copolymer

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer : A new biomaterial for protein drug delivery. / Qiu, Bo; Stefanos, Simon; Ma, Jianglin; Lalloo, Anita; Perry, Barbara A.; Leibowitz, Michael J; Sinko, Patrick J.; Stein, Stanley.

In: Biomaterials, Vol. 24, No. 1, 01.2003, p. 11-18.

Research output: Contribution to journalArticle

Qiu, Bo ; Stefanos, Simon ; Ma, Jianglin ; Lalloo, Anita ; Perry, Barbara A. ; Leibowitz, Michael J ; Sinko, Patrick J. ; Stein, Stanley. / A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer : A new biomaterial for protein drug delivery. In: Biomaterials. 2003 ; Vol. 24, No. 1. pp. 11-18.
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