A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: A new biomaterial for protein drug delivery

Bo Qiu; Simon Stefanos; Jianglin Ma; Anita Lalloo; Barbara A. Perry; Michael J Leibowitz; Patrick J. Sinko; Stanley Stein

doi:10.1016/S0142-9612(02)00227-2

A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: A new biomaterial for protein drug delivery

Bo Qiu, Simon Stefanos, Jianglin Ma, Anita Lalloo, Barbara A. Perry, Michael J Leibowitz, Patrick J. Sinko, Stanley Stein

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.

Original language	English (US)
Pages (from-to)	11-18
Number of pages	8
Journal	Biomaterials
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/S0142-9612(02)00227-2
State	Published - Jan 2003
Externally published	Yes

Keywords

Hydrogel
In situ cross-linking
Poly(ethylene glycol)
Protein drug delivery
Thiol-containing copolymer

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

Access to Document

10.1016/S0142-9612(02)00227-2

Fingerprint Dive into the research topics of 'A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: A new biomaterial for protein drug delivery'. Together they form a unique fingerprint.

Cite this

A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer : A new biomaterial for protein drug delivery. / Qiu, Bo; Stefanos, Simon; Ma, Jianglin; Lalloo, Anita; Perry, Barbara A.; Leibowitz, Michael J; Sinko, Patrick J.; Stein, Stanley.

In: Biomaterials, Vol. 24, No. 1, 01.2003, p. 11-18.

Research output: Contribution to journal › Article › peer-review

@article{de3e18ded175471bb90de9be110351b9,

title = "A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: A new biomaterial for protein drug delivery",

abstract = "A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.",

keywords = "Hydrogel, In situ cross-linking, Poly(ethylene glycol), Protein drug delivery, Thiol-containing copolymer",

author = "Bo Qiu and Simon Stefanos and Jianglin Ma and Anita Lalloo and Perry, {Barbara A.} and Leibowitz, {Michael J} and Sinko, {Patrick J.} and Stanley Stein",

year = "2003",

month = jan,

doi = "10.1016/S0142-9612(02)00227-2",

language = "English (US)",

volume = "24",

pages = "11--18",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer

T2 - A new biomaterial for protein drug delivery

AU - Qiu, Bo

AU - Stefanos, Simon

AU - Ma, Jianglin

AU - Lalloo, Anita

AU - Perry, Barbara A.

AU - Leibowitz, Michael J

AU - Sinko, Patrick J.

AU - Stein, Stanley

PY - 2003/1

Y1 - 2003/1

N2 - A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.

AB - A new poly(ethylene glycol)-based copolymer containing multiple thiol (-SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions. No organic solvent, elevated temperature, or harsh pH is required in the formulation or patient administration processes, making it particularly useful for delivery of fragile therapeutics, such as proteins. The in vitro release of fluorescein-labeled bovine serum albumin and the in vivo release of the model proteins, erythropoietin, RANTES and three PEG-conjugated RANTES derivatives showed sustained release for 2-4 weeks and demonstrated prolonged biological activity of the released proteins in animals.

KW - Hydrogel

KW - In situ cross-linking

KW - Poly(ethylene glycol)

KW - Protein drug delivery

KW - Thiol-containing copolymer

UR - http://www.scopus.com/inward/record.url?scp=0037209905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037209905&partnerID=8YFLogxK

U2 - 10.1016/S0142-9612(02)00227-2

DO - 10.1016/S0142-9612(02)00227-2

M3 - Article

C2 - 12417173

AN - SCOPUS:0037209905

VL - 24

SP - 11

EP - 18

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 1

ER -

A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: A new biomaterial for protein drug delivery

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this