A human genome map of comparative anchor tagged sequences

Z. Q. Chen, J. A. Lautenberger, Leslie A Lyons, L. McKenzie, S. J. O'Brien

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.

Original languageEnglish (US)
Pages (from-to)477-484
Number of pages8
JournalJournal of Heredity
Volume90
Issue number4
DOIs
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Human Genome
genome
chromosome mapping
Genes
mice
genes
Radiation Hybrid Mapping
loci
Hybrid Cells
Chromosome Mapping
cell lines
genetic polymorphism
Cell Line
Polymerase Chain Reaction
genetic markers
animals

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Chen, Z. Q., Lautenberger, J. A., Lyons, L. A., McKenzie, L., & O'Brien, S. J. (1999). A human genome map of comparative anchor tagged sequences. Journal of Heredity, 90(4), 477-484. https://doi.org/10.1093/jhered/90.4.477

A human genome map of comparative anchor tagged sequences. / Chen, Z. Q.; Lautenberger, J. A.; Lyons, Leslie A; McKenzie, L.; O'Brien, S. J.

In: Journal of Heredity, Vol. 90, No. 4, 07.1999, p. 477-484.

Research output: Contribution to journalArticle

Chen, ZQ, Lautenberger, JA, Lyons, LA, McKenzie, L & O'Brien, SJ 1999, 'A human genome map of comparative anchor tagged sequences', Journal of Heredity, vol. 90, no. 4, pp. 477-484. https://doi.org/10.1093/jhered/90.4.477
Chen, Z. Q. ; Lautenberger, J. A. ; Lyons, Leslie A ; McKenzie, L. ; O'Brien, S. J. / A human genome map of comparative anchor tagged sequences. In: Journal of Heredity. 1999 ; Vol. 90, No. 4. pp. 477-484.
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