A human genome map of comparative anchor tagged sequences

Z. Q. Chen; J. A. Lautenberger; Leslie A Lyons; L. McKenzie; S. J. O'Brien

doi:10.1093/jhered/90.4.477

A human genome map of comparative anchor tagged sequences

Z. Q. Chen, J. A. Lautenberger, Leslie A Lyons, L. McKenzie, S. J. O'Brien

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.

Original language	English (US)
Pages (from-to)	477-484
Number of pages	8
Journal	Journal of Heredity
Volume	90
Issue number	4
DOIs	https://doi.org/10.1093/jhered/90.4.477
State	Published - Jul 1999
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Genetics
Genetics(clinical)

Access to Document

10.1093/jhered/90.4.477

Fingerprint Dive into the research topics of 'A human genome map of comparative anchor tagged sequences'. Together they form a unique fingerprint.

Cite this

@article{4991d7965fc945a9bc094bf67510a87c,

title = "A human genome map of comparative anchor tagged sequences",

abstract = "Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.",

author = "Chen, {Z. Q.} and Lautenberger, {J. A.} and Lyons, {Leslie A} and L. McKenzie and O'Brien, {S. J.}",

year = "1999",

month = jul,

doi = "10.1093/jhered/90.4.477",

language = "English (US)",

volume = "90",

pages = "477--484",

journal = "Journal of Heredity",

issn = "0022-1503",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - A human genome map of comparative anchor tagged sequences

AU - Chen, Z. Q.

AU - Lautenberger, J. A.

AU - Lyons, Leslie A

AU - McKenzie, L.

AU - O'Brien, S. J.

PY - 1999/7

Y1 - 1999/7

N2 - Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.

AB - Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.

UR - http://www.scopus.com/inward/record.url?scp=0032879329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032879329&partnerID=8YFLogxK

U2 - 10.1093/jhered/90.4.477

DO - 10.1093/jhered/90.4.477

M3 - Article

C2 - 10485137

AN - SCOPUS:0032879329

VL - 90

SP - 477

EP - 484

JO - Journal of Heredity

JF - Journal of Heredity

SN - 0022-1503

IS - 4

ER -