A human genome map of comparative anchor tagged sequences

Z. Q. Chen, J. A. Lautenberger, Leslie A Lyons, L. McKenzie, S. J. O'Brien

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.

Original languageEnglish (US)
Pages (from-to)477-484
Number of pages8
JournalJournal of Heredity
Volume90
Issue number4
DOIs
StatePublished - Jul 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Chen, Z. Q., Lautenberger, J. A., Lyons, L. A., McKenzie, L., & O'Brien, S. J. (1999). A human genome map of comparative anchor tagged sequences. Journal of Heredity, 90(4), 477-484. https://doi.org/10.1093/jhered/90.4.477