A highly divergent simian immunodeficiency virus (SIVstm) recovered from stored stump-tailed macaque tissues

Arifa S. Khan, Teresa A. Galvin, Linda J Lowenstine, Myra B. Jennings, Murray B. Gardner, Charles E. Buckler

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Abstract

We report here the results of molecular analysis of a simian immunodeficiency virus (designated SIVstm) which was isolated from a rhesus monkey inoculated with stored lymph node tissue of an Asian stump-tailed macaque. The latter monkey had died in 1977 during an epidemic of acquired immunodeficiency and lymphoma at the California Regional Primate Research Center (L. J. Lowenstine, N. W. Lerche, P. A. Marx, M. B. Gardner, and N. C. Pedersen, p. 174-176, in M. Girard and L. Valette, ed., Retroviruses of Human AIDS and Related Animal Viruses, 1988). Nucleotide sequence analysis of the gag and env regions indicates that SIVstm is an ancient member of the SIV/human immunodeficiency virus type 2 group; it is quite divergent from known SIVs isolated from African sooty mangabeys as well as from Asian macaques. Furthermore, of all SIV strains described to date, SIVstm is the most closely related to human immunodeficiency virus type 2.

Original languageEnglish (US)
Pages (from-to)7061-7065
Number of pages5
JournalJournal of Virology
Volume65
Issue number12
StatePublished - Dec 1991

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ASJC Scopus subject areas

  • Immunology

Cite this

Khan, A. S., Galvin, T. A., Lowenstine, L. J., Jennings, M. B., Gardner, M. B., & Buckler, C. E. (1991). A highly divergent simian immunodeficiency virus (SIVstm) recovered from stored stump-tailed macaque tissues. Journal of Virology, 65(12), 7061-7065.