A high-sensitivity small animal SPECT system

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Medical imaging using single gamma-ray-emitting radionuclides typically makes use of parallel hole collimators or pinholes in order to achieve good spatial resolution. However, a tradeoff in sensitivity is inherent in the use of a collimator, and modern preclinical single photon emission computed tomography (SPECT) systems detect a very small fraction of emitted gamma rays, often less than 0.1%. A system for small animal SPECT imaging which uses no collimators could potentially achieve very high sensitivity - several tens of percent - with reasonably sized detectors. This would allow two significant improvements in preclinical studies: images could be obtained more rapidly, allowing higher throughput for screening applications, or for dynamic processes to be observed with very good time resolution; and images could be obtained with less radioactive tracer, making possible the in vivo imaging of low-capacity receptor systems, aiding research into new tracer compounds, and reducing the cost and easing the regulatory burden of an experiment. Of course, a system with no collimator will not be able to approach the submillimeter spatial resolutions produced by the most advanced pinhole and collimated systems, but a high-sensitivity system with resolution of order 1 cm could nonetheless find significant and new use in the many molecular imaging applications which do not require good spatial resolution - for example, screening applications for drug development or new imaging agents. Rather than as an alternative to high-resolution SPECT systems, the high-sensitivity system is proposed as a radiotracer alternative to optical imaging for small animals. We have developed a prototype system for mouse imaging applications. The scanner consists of two large, thin, closely spaced scintillation detectors. Simulation studies indicate that a FWHM spatial resolution of 7 mm is possible. In an in vivo mouse imaging study using the 99mTc labeled tracer MAG-3, the sensitivity of the system is measured to be 40%. Simple projection images created by analytically combining the two detectors' data show sufficient resolution to observe the dynamic distribution of the radiotracer in the mouse.

Original languageEnglish (US)
Pages (from-to)1291-1305
Number of pages15
JournalPhysics in Medicine and Biology
Volume54
Issue number5
DOIs
StatePublished - 2009

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Single-Photon Emission-Computed Tomography
Gamma Rays
Radioactive Tracers
Preclinical Drug Evaluations
Molecular Imaging
Optical Imaging
Diagnostic Imaging
Radioisotopes
Costs and Cost Analysis
Research

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A high-sensitivity small animal SPECT system. / Mitchell, Gregory; Cherry, Simon R.

In: Physics in Medicine and Biology, Vol. 54, No. 5, 2009, p. 1291-1305.

Research output: Contribution to journalArticle

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