A hierarchical non-homogenous Poisson model for meta-analysis of adenoma counts

Carolyn M. Rutter, Onchee Yu, Diana L Miglioretti

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We use a hierarchical model for a meta-analysis that combines information from autopsy studies of adenoma prevalence and counts. The studies we included reported findings using a variety of adenoma prevalence groupings and age categories. We use a non-homogeneous Poisson model for multinomial bin probabilities. The Poisson model allows risk to depend on age and sex, and incorporates extra-Poisson variability. We evaluate model fit using the posterior predicted distribution of adenoma prevalence reported by the studies included in our analyses and validate our model using adenoma prevalence reported by more recent colonoscopy studies. For 1990, the estimated adenoma prevalence among Americans at age 60 is 40.3 per cent for men compared to 29.2 per cent for women.

Original languageEnglish (US)
Pages (from-to)98-109
Number of pages12
JournalStatistics in Medicine
Volume26
Issue number1
DOIs
StatePublished - Jan 15 2007
Externally publishedYes

Keywords

  • Bayesian estimation
  • Goodness of fit
  • Model validation

ASJC Scopus subject areas

  • Epidemiology

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