Abstract
A small population of B cells exists in lymphoid tissues and body cavities of mice that is distinct in development, phenotype, and function from the majority (B-2) B cell population. This population, originally termed "Ly-1" and now "B-1," has received renewed interest as an innate-like B cell population of fetal-derived hematopoiesis, responsible for natural Ab production and rapid immune responses. Molecular analyses have begun to define fetal and adult hematopoiesis, while cell-fate mapping studies have revealed complex developmental origins of B-1 cells. Together the studies provide a more detailed understanding of B-1 cell regulation and function. This review outlines studies that defined B-1 cells as natural Ab-and cytokine-producing B cells of fetal origin, with a focus on work conducted by R.R. Hardy, an early pioneer and codiscoverer of B-1 cells, whose seminal contributions enhanced our understanding of this enigmatic B cell population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3387-3394 |
| Number of pages | 8 |
| Journal | Journal of Immunology |
| Volume | 199 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 15 2017 |
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ASJC Scopus subject areas
- Immunology
Cite this
A hard(y) look at B-1 cell development and function. / Baumgarth, Nicole.
In: Journal of Immunology, Vol. 199, No. 10, 15.11.2017, p. 3387-3394.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - A hard(y) look at B-1 cell development and function
AU - Baumgarth, Nicole
PY - 2017/11/15
Y1 - 2017/11/15
N2 - A small population of B cells exists in lymphoid tissues and body cavities of mice that is distinct in development, phenotype, and function from the majority (B-2) B cell population. This population, originally termed "Ly-1" and now "B-1," has received renewed interest as an innate-like B cell population of fetal-derived hematopoiesis, responsible for natural Ab production and rapid immune responses. Molecular analyses have begun to define fetal and adult hematopoiesis, while cell-fate mapping studies have revealed complex developmental origins of B-1 cells. Together the studies provide a more detailed understanding of B-1 cell regulation and function. This review outlines studies that defined B-1 cells as natural Ab-and cytokine-producing B cells of fetal origin, with a focus on work conducted by R.R. Hardy, an early pioneer and codiscoverer of B-1 cells, whose seminal contributions enhanced our understanding of this enigmatic B cell population.
AB - A small population of B cells exists in lymphoid tissues and body cavities of mice that is distinct in development, phenotype, and function from the majority (B-2) B cell population. This population, originally termed "Ly-1" and now "B-1," has received renewed interest as an innate-like B cell population of fetal-derived hematopoiesis, responsible for natural Ab production and rapid immune responses. Molecular analyses have begun to define fetal and adult hematopoiesis, while cell-fate mapping studies have revealed complex developmental origins of B-1 cells. Together the studies provide a more detailed understanding of B-1 cell regulation and function. This review outlines studies that defined B-1 cells as natural Ab-and cytokine-producing B cells of fetal origin, with a focus on work conducted by R.R. Hardy, an early pioneer and codiscoverer of B-1 cells, whose seminal contributions enhanced our understanding of this enigmatic B cell population.
UR - http://www.scopus.com/inward/record.url?scp=85033397975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033397975&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1700943
DO - 10.4049/jimmunol.1700943
M3 - Review article
C2 - 29109178
AN - SCOPUS:85033397975
VL - 199
SP - 3387
EP - 3394
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 10
ER -