A Grade IV Glioblastoma with an Oligodendroglial Component (GBM-O) in a Horse

B. Gericota, Monica R Aleman, T. A. Kozikowski, Patricia Pesavento, A. W. Bollen, John E Madigan, Robert Higgins

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A 4-year-old Dutch warmblood mare was presented with a 10-month history of ataxia and proprioceptive deficits. Computed tomography defined a large, non-contrast enhancing mass in the left cerebral hemisphere. Necropsy examination revealed a tumour that effaced much of the piriform and temporal lobes. Microscopically the lesion was classified as a grade IV glioblastoma with an oligodendroglial component (GBM-O). The tumour was composed of highly pleomorphic cells organized in different patterns within a fibrillary stroma. There were multiple foci of necrosis. At the periphery of the tumour neoplastic oligodendroglioma-like cells were embedded in an extracellular mucinous matrix. Most neoplastic cells were strongly immunoreactive for glial fibrillary acidic protein; however, the oligodendroglioma cells did not express this marker. Cells forming microvascular proliferations were positively labelled for expression of factor VIII and smooth muscle actin. All neoplastic cells were negative for Neu-N and synaptophysin. The proliferation index was up to 5%. All neoplastic cells and normal brain tissue from the horse were uniformly negative for expression of epidermal growth factor receptor (EGFR), EGFR vIII mutant and the phosphatase and tensin homologue (PTEN) compared with positive control human GBM tissue. To our knowledge this is the first report of a GBM-O in the horse.

Original languageEnglish (US)
Pages (from-to)332-335
Number of pages4
JournalJournal of Comparative Pathology
Volume142
Issue number4
DOIs
StatePublished - May 2010

Keywords

  • Astrocytoma
  • Glioblastoma
  • Horse
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Fingerprint Dive into the research topics of 'A Grade IV Glioblastoma with an Oligodendroglial Component (GBM-O) in a Horse'. Together they form a unique fingerprint.

  • Cite this