A genomic regulatory network for development

Eric H. Davidson, Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou Hwa Yuh, Takuya Minokawa, Gabriele Amore, Veronica Hinman, César Arenas-Mena, Ochan Otim, Charles Brown, Carolina B. Livi, Pei Yun Lee, Roger Revilla, Alistair G. Rust, Zheng Jun Pan, Maria J. Schilstra, Peter J.C. Clarke, Maria I. Arnone & 5 others Lee Rowen, R. Andrew Cameron, David R. McClay, Leroy Hood, Hamid Bolouri

Research output: Contribution to journalReview article

1072 Citations (Scopus)

Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

Original languageEnglish (US)
Pages (from-to)1669-1678
Number of pages10
JournalScience
Volume295
Issue number5560
DOIs
StatePublished - Mar 1 2002
Externally publishedYes

Fingerprint

Gene Regulatory Networks
Embryonic Structures
Endoderm
Embryology
Sea Urchins
Mesoderm
Genes

ASJC Scopus subject areas

  • General

Cite this

Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., ... Bolouri, H. (2002). A genomic regulatory network for development. Science, 295(5560), 1669-1678. https://doi.org/10.1126/science.1069883

A genomic regulatory network for development. / Davidson, Eric H.; Rast, Jonathan P.; Oliveri, Paola; Ransick, Andrew; Calestani, Cristina; Yuh, Chiou Hwa; Minokawa, Takuya; Amore, Gabriele; Hinman, Veronica; Arenas-Mena, César; Otim, Ochan; Brown, Charles; Livi, Carolina B.; Lee, Pei Yun; Revilla, Roger; Rust, Alistair G.; Pan, Zheng Jun; Schilstra, Maria J.; Clarke, Peter J.C.; Arnone, Maria I.; Rowen, Lee; Cameron, R. Andrew; McClay, David R.; Hood, Leroy; Bolouri, Hamid.

In: Science, Vol. 295, No. 5560, 01.03.2002, p. 1669-1678.

Research output: Contribution to journalReview article

Davidson, EH, Rast, JP, Oliveri, P, Ransick, A, Calestani, C, Yuh, CH, Minokawa, T, Amore, G, Hinman, V, Arenas-Mena, C, Otim, O, Brown, C, Livi, CB, Lee, PY, Revilla, R, Rust, AG, Pan, ZJ, Schilstra, MJ, Clarke, PJC, Arnone, MI, Rowen, L, Cameron, RA, McClay, DR, Hood, L & Bolouri, H 2002, 'A genomic regulatory network for development', Science, vol. 295, no. 5560, pp. 1669-1678. https://doi.org/10.1126/science.1069883
Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh CH et al. A genomic regulatory network for development. Science. 2002 Mar 1;295(5560):1669-1678. https://doi.org/10.1126/science.1069883
Davidson, Eric H. ; Rast, Jonathan P. ; Oliveri, Paola ; Ransick, Andrew ; Calestani, Cristina ; Yuh, Chiou Hwa ; Minokawa, Takuya ; Amore, Gabriele ; Hinman, Veronica ; Arenas-Mena, César ; Otim, Ochan ; Brown, Charles ; Livi, Carolina B. ; Lee, Pei Yun ; Revilla, Roger ; Rust, Alistair G. ; Pan, Zheng Jun ; Schilstra, Maria J. ; Clarke, Peter J.C. ; Arnone, Maria I. ; Rowen, Lee ; Cameron, R. Andrew ; McClay, David R. ; Hood, Leroy ; Bolouri, Hamid. / A genomic regulatory network for development. In: Science. 2002 ; Vol. 295, No. 5560. pp. 1669-1678.
@article{56c5a9ffa41d45a2959c1365138f3941,
title = "A genomic regulatory network for development",
abstract = "Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.",
author = "Davidson, {Eric H.} and Rast, {Jonathan P.} and Paola Oliveri and Andrew Ransick and Cristina Calestani and Yuh, {Chiou Hwa} and Takuya Minokawa and Gabriele Amore and Veronica Hinman and C{\'e}sar Arenas-Mena and Ochan Otim and Charles Brown and Livi, {Carolina B.} and Lee, {Pei Yun} and Roger Revilla and Rust, {Alistair G.} and Pan, {Zheng Jun} and Schilstra, {Maria J.} and Clarke, {Peter J.C.} and Arnone, {Maria I.} and Lee Rowen and Cameron, {R. Andrew} and McClay, {David R.} and Leroy Hood and Hamid Bolouri",
year = "2002",
month = "3",
day = "1",
doi = "10.1126/science.1069883",
language = "English (US)",
volume = "295",
pages = "1669--1678",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5560",

}

TY - JOUR

T1 - A genomic regulatory network for development

AU - Davidson, Eric H.

AU - Rast, Jonathan P.

AU - Oliveri, Paola

AU - Ransick, Andrew

AU - Calestani, Cristina

AU - Yuh, Chiou Hwa

AU - Minokawa, Takuya

AU - Amore, Gabriele

AU - Hinman, Veronica

AU - Arenas-Mena, César

AU - Otim, Ochan

AU - Brown, Charles

AU - Livi, Carolina B.

AU - Lee, Pei Yun

AU - Revilla, Roger

AU - Rust, Alistair G.

AU - Pan, Zheng Jun

AU - Schilstra, Maria J.

AU - Clarke, Peter J.C.

AU - Arnone, Maria I.

AU - Rowen, Lee

AU - Cameron, R. Andrew

AU - McClay, David R.

AU - Hood, Leroy

AU - Bolouri, Hamid

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

AB - Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

UR - http://www.scopus.com/inward/record.url?scp=0036500609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036500609&partnerID=8YFLogxK

U2 - 10.1126/science.1069883

DO - 10.1126/science.1069883

M3 - Review article

VL - 295

SP - 1669

EP - 1678

JO - Science

JF - Science

SN - 0036-8075

IS - 5560

ER -