A genomic regulatory network for development

Eric H. Davidson, Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou Hwa Yuh, Takuya Minokawa, Gabriele Amore, Veronica Hinman, César Arenas-Mena, Ochan Otim, Charles Brown, Carolina B. Livi, Pei Yun Lee, Roger Revilla, Alistair G. Rust, Zheng Jun Pan, Maria J. Schilstra, Peter J.C. Clarke, Maria I. ArnoneLee Rowen, R. Andrew Cameron, David R. McClay, Leroy Hood, Hamid Bolouri

Research output: Contribution to journalReview article

1100 Scopus citations

Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

Original languageEnglish (US)
Pages (from-to)1669-1678
Number of pages10
JournalScience
Volume295
Issue number5560
DOIs
StatePublished - Mar 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., Otim, O., Brown, C., Livi, C. B., Lee, P. Y., Revilla, R., Rust, A. G., Pan, Z. J., Schilstra, M. J., Clarke, P. J. C., ... Bolouri, H. (2002). A genomic regulatory network for development. Science, 295(5560), 1669-1678. https://doi.org/10.1126/science.1069883