A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Peter Broderick; Luis Carvajal-Carmona; Alan M. Pittman; Emily Webb; Kimberley Howarth; Andrew Rowan; Steven Lubbe; Sarah Spain; Kate Sullivan; Sarah Fielding; Emma Jaeger; Jayaram Vijayakrishnan; Zoe Kemp; Maggie Gorman; Ian Chandler; Elli Papaemmanuil; Steven Penegar; Wendy Wood; Gabrielle Sellick; Mobshra Qureshi; Ana Teixeira; Enric Domingo; Ella Barclay; Lynn Martin; Oliver Sieber; David Kerr; Richard Gray; Julian Peto; Jean Baptiste Cazier; Ian Tomlinson; Richard S. Houlston

doi:10.1038/ng.2007.18

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Peter Broderick, Luis Carvajal-Carmona, Alan M. Pittman, Emily Webb, Kimberley Howarth, Andrew Rowan, Steven Lubbe, Sarah Spain, Kate Sullivan, Sarah Fielding, Emma Jaeger, Jayaram Vijayakrishnan, Zoe Kemp, Maggie Gorman, Ian Chandler, Elli Papaemmanuil, Steven Penegar, Wendy Wood, Gabrielle Sellick, Mobshra QureshiAna Teixeira, Enric Domingo, Ella Barclay, Lynn Martin, Oliver Sieber, David Kerr, Richard Gray, Julian Peto, Jean Baptiste Cazier, Ian Tomlinson, Richard S. Houlston

Research output: Contribution to journal › Article › peer-review

424 Scopus citations

Abstract

To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P_trend = 1.0 × 10^-12).

Original language	English (US)
Pages (from-to)	1315-1317
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	11
DOIs	https://doi.org/10.1038/ng.2007.18
State	Published - Nov 2007
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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Broderick, P., Carvajal-Carmona, L., Pittman, A. M., Webb, E., Howarth, K., Rowan, A., Lubbe, S., Spain, S., Sullivan, K., Fielding, S., Jaeger, E., Vijayakrishnan, J., Kemp, Z., Gorman, M., Chandler, I., Papaemmanuil, E., Penegar, S., Wood, W., Sellick, G., ... Houlston, R. S. (2007). A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nature Genetics, 39(11), 1315-1317. https://doi.org/10.1038/ng.2007.18

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. / Broderick, Peter; Carvajal-Carmona, Luis; Pittman, Alan M.; Webb, Emily; Howarth, Kimberley; Rowan, Andrew; Lubbe, Steven; Spain, Sarah; Sullivan, Kate; Fielding, Sarah; Jaeger, Emma; Vijayakrishnan, Jayaram; Kemp, Zoe; Gorman, Maggie; Chandler, Ian; Papaemmanuil, Elli; Penegar, Steven; Wood, Wendy; Sellick, Gabrielle; Qureshi, Mobshra; Teixeira, Ana; Domingo, Enric; Barclay, Ella; Martin, Lynn; Sieber, Oliver; Kerr, David; Gray, Richard; Peto, Julian; Cazier, Jean Baptiste; Tomlinson, Ian; Houlston, Richard S.

In: Nature Genetics, Vol. 39, No. 11, 11.2007, p. 1315-1317.

Research output: Contribution to journal › Article › peer-review

Broderick, P, Carvajal-Carmona, L, Pittman, AM, Webb, E, Howarth, K, Rowan, A, Lubbe, S, Spain, S, Sullivan, K, Fielding, S, Jaeger, E, Vijayakrishnan, J, Kemp, Z, Gorman, M, Chandler, I, Papaemmanuil, E, Penegar, S, Wood, W, Sellick, G, Qureshi, M, Teixeira, A, Domingo, E, Barclay, E, Martin, L, Sieber, O, Kerr, D, Gray, R, Peto, J, Cazier, JB, Tomlinson, I & Houlston, RS 2007, 'A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk', Nature Genetics, vol. 39, no. 11, pp. 1315-1317. https://doi.org/10.1038/ng.2007.18

Broderick, Peter ; Carvajal-Carmona, Luis ; Pittman, Alan M. ; Webb, Emily ; Howarth, Kimberley ; Rowan, Andrew ; Lubbe, Steven ; Spain, Sarah ; Sullivan, Kate ; Fielding, Sarah ; Jaeger, Emma ; Vijayakrishnan, Jayaram ; Kemp, Zoe ; Gorman, Maggie ; Chandler, Ian ; Papaemmanuil, Elli ; Penegar, Steven ; Wood, Wendy ; Sellick, Gabrielle ; Qureshi, Mobshra ; Teixeira, Ana ; Domingo, Enric ; Barclay, Ella ; Martin, Lynn ; Sieber, Oliver ; Kerr, David ; Gray, Richard ; Peto, Julian ; Cazier, Jean Baptiste ; Tomlinson, Ian ; Houlston, Richard S. / A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. In: Nature Genetics. 2007 ; Vol. 39, No. 11. pp. 1315-1317.

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abstract = "To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10-12).",

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A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

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