Abstract
To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10-12).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1315-1317 |
| Number of pages | 3 |
| Journal | Nature Genetics |
| Volume | 39 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. / Broderick, Peter; Carvajal-Carmona, Luis; Pittman, Alan M.; Webb, Emily; Howarth, Kimberley; Rowan, Andrew; Lubbe, Steven; Spain, Sarah; Sullivan, Kate; Fielding, Sarah; Jaeger, Emma; Vijayakrishnan, Jayaram; Kemp, Zoe; Gorman, Maggie; Chandler, Ian; Papaemmanuil, Elli; Penegar, Steven; Wood, Wendy; Sellick, Gabrielle; Qureshi, Mobshra; Teixeira, Ana; Domingo, Enric; Barclay, Ella; Martin, Lynn; Sieber, Oliver; Kerr, David; Gray, Richard; Peto, Julian; Cazier, Jean Baptiste; Tomlinson, Ian; Houlston, Richard S.
In: Nature Genetics, Vol. 39, No. 11, 11.2007, p. 1315-1317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
AU - Broderick, Peter
AU - Carvajal-Carmona, Luis
AU - Pittman, Alan M.
AU - Webb, Emily
AU - Howarth, Kimberley
AU - Rowan, Andrew
AU - Lubbe, Steven
AU - Spain, Sarah
AU - Sullivan, Kate
AU - Fielding, Sarah
AU - Jaeger, Emma
AU - Vijayakrishnan, Jayaram
AU - Kemp, Zoe
AU - Gorman, Maggie
AU - Chandler, Ian
AU - Papaemmanuil, Elli
AU - Penegar, Steven
AU - Wood, Wendy
AU - Sellick, Gabrielle
AU - Qureshi, Mobshra
AU - Teixeira, Ana
AU - Domingo, Enric
AU - Barclay, Ella
AU - Martin, Lynn
AU - Sieber, Oliver
AU - Kerr, David
AU - Gray, Richard
AU - Peto, Julian
AU - Cazier, Jean Baptiste
AU - Tomlinson, Ian
AU - Houlston, Richard S.
PY - 2007/11
Y1 - 2007/11
N2 - To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10-12).
AB - To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10-12).
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U2 - 10.1038/ng.2007.18
DO - 10.1038/ng.2007.18
M3 - Article
VL - 39
SP - 1315
EP - 1317
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -