Abstract
A concise, prototypical, and stereoselective strategy for the synthesis of therapeutically and immunologically significant glycosphingolipids has been developed. This strategy provides a universal platform for glycosphingolipid synthesis by block coupling of enzymatically prepared free oligosaccharideglycans to lipids using glycosyl N-phenyltrifluoroacetimidates as efficient activated intermediates. As demonstrated here, two different types of glycosphingolipids were obtained in excellent yields using the method.
Original language | English (US) |
---|---|
Pages (from-to) | 4315-4320 |
Number of pages | 6 |
Journal | European Journal of Organic Chemistry |
Volume | 2016 |
Issue number | 25 |
DOIs | |
State | Published - Sep 1 2016 |
Keywords
- Enzyme catalysis
- Glycosphingolipids
- Glycosylation
- Medicinal chemistry
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry