A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin

Kristina L. Bezold, Justin F. Shaffer, Jaskiran K. Khosa, Elaine R. Hoye, Samantha P. Harris

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: Cardiac myosin-binding protein C (cMyBP-C) regulates heart muscle contraction by influencing actomyosin interactions. Results: Amino acids within the tri-helix bundle of the M-domain contribute to the functional effects of cMyBP-C. Conclusion: Amino acids outside of phosphorylation sites influence function of the M-domain. Significance: The tri-helix bundle is important to the regulatory role of cMyBP-C, likely through actin-binding interactions.

Original languageEnglish (US)
Pages (from-to)21496-21505
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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