A folding variant of α-lactalbumin with bactericidal activity against Streptococcus pneumoniae

Anders Håkansson, Malin Svensson, Ann Kristin Mossberg, Hemant Sabharwal, Sara Linse, Irene Lazou, Bo Lönnerdal, Catharina Svanborg

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

α-lactalbumin from human milk whey, but fluctuating tertiary structure. Native α-lactalbumin could be converted to the active bactericidal form by ion-exchange chromatography in the presence of a cofactor from human milk casein, characterized as a C18:1 fatty acid. Analysis of the antibacterial spectrum showed selectivity for streptococci; Gram-negative and other Gram-positive bacteria were resistant. The folding variant of α-lactalbumin is a new example of naturally occurring molecules with antimicrobial activity.

Original languageEnglish (US)
Pages (from-to)589-600
Number of pages12
JournalMolecular Microbiology
Volume35
Issue number3
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Microbiology

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    Håkansson, A., Svensson, M., Mossberg, A. K., Sabharwal, H., Linse, S., Lazou, I., Lönnerdal, B., & Svanborg, C. (2000). A folding variant of α-lactalbumin with bactericidal activity against Streptococcus pneumoniae. Molecular Microbiology, 35(3), 589-600. https://doi.org/10.1046/j.1365-2958.2000.01728.x