A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection

Michael J. Bennett, Robert W. Malone, Michael H. Nantz

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The synthesis of novel 2,3-acyloxy-1-propylammonium salts is described. The route incorporates the use of glycidol and N-methyl-2-aminoethanol to prepare cationic lipids with control of absolute stereochemistry and regioselective introduction of fatty acid side chains.

Original languageEnglish (US)
Pages (from-to)2207-2210
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number13
DOIs
StatePublished - Mar 27 1995

Fingerprint

glycidol
Polynucleotides
Stereochemistry
Ethanolamine
Ammonium Compounds
Transfection
Fatty Acids
Salts
Lipids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection. / Bennett, Michael J.; Malone, Robert W.; Nantz, Michael H.

In: Tetrahedron Letters, Vol. 36, No. 13, 27.03.1995, p. 2207-2210.

Research output: Contribution to journalArticle

Bennett, Michael J. ; Malone, Robert W. ; Nantz, Michael H. / A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection. In: Tetrahedron Letters. 1995 ; Vol. 36, No. 13. pp. 2207-2210.
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