A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection

Michael J. Bennett, Robert W. Malone, Michael H. Nantz

Research output: Contribution to journalArticle

35 Scopus citations


The synthesis of novel 2,3-acyloxy-1-propylammonium salts is described. The route incorporates the use of glycidol and N-methyl-2-aminoethanol to prepare cationic lipids with control of absolute stereochemistry and regioselective introduction of fatty acid side chains.

Original languageEnglish (US)
Pages (from-to)2207-2210
Number of pages4
JournalTetrahedron Letters
Issue number13
StatePublished - Mar 27 1995


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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