A fiber matrix model of capillary permeability

F. E. Curry, C. C. Michel

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

The observation that ferritin is excluded from the luminal vesicles and the luminal surface of endothelial cells has led one of us to reintroduce the idea that the molecular sieving properties of the capillary wall may reside in an endocapillary layer rather than in the dimensions of pores through or between the endothelial cells. It is suggested that the endocapillary layer is a three-dimensional network formed by the fibrous chains of the membrane glycoproteins of the endothelial cell coat reinforced by the absorption of plasma proteins. It may be identified with the ruthenium red staining layer described by Luft (1966). The latter not only appears to line the luminal surface of the capillary but also appears to fill the wide regions of the intercellular clefts and merge with the basal lamina. It is found covering the fenestrations when these are present and can also be seen lining the cytoplasmic vesicles. In this short paper, we wish to draw attention to the possible relationships for flow and diffusion through such a membrane, and so offer a quantitative basis for assessing the theory.

Original languageEnglish (US)
Pages (from-to)96-99
Number of pages4
JournalMicrovascular Research
Volume20
Issue number1
StatePublished - 1980

Fingerprint

Myelinated Nerve Fibers
Endothelial cells
Capillary Permeability
Endothelial Cells
Fibers
Cytoplasmic Vesicles
Glycocalyx
Ruthenium Red
Membrane Glycoproteins
Ferritins
Linings
Basement Membrane
Blood Proteins
Staining and Labeling
Membranes

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

Cite this

Curry, F. E., & Michel, C. C. (1980). A fiber matrix model of capillary permeability. Microvascular Research, 20(1), 96-99.

A fiber matrix model of capillary permeability. / Curry, F. E.; Michel, C. C.

In: Microvascular Research, Vol. 20, No. 1, 1980, p. 96-99.

Research output: Contribution to journalArticle

Curry, FE & Michel, CC 1980, 'A fiber matrix model of capillary permeability', Microvascular Research, vol. 20, no. 1, pp. 96-99.
Curry, F. E. ; Michel, C. C. / A fiber matrix model of capillary permeability. In: Microvascular Research. 1980 ; Vol. 20, No. 1. pp. 96-99.
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