A feline CD2 homologue interacts with human red blood cells

Masayuki Shimojima, Yorihiro Nishimura, Takayuki Miyazawa, Kentaro Kato, Kazuya Nakamura, Yoshihiro Izumiya, Hiroomi Akashi, Yukinobu Tohya

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A cDNA encoding a feline homologue of CD2 (fCD2) was identified. Several amino acids (aa) important for ligand interaction, molecular folding or signal transduction, found in other mammalian CD2, were found to be highly conserved in the predicted fCD2 aa sequence. fCD2-expressing cells were able to form rosettes with human red blood cells (probably via human CD58), and the rosette formation was inhibited by an anti-fCD2 monoclonal antibody. These results are indicative of the similarity of feline and human CD2 structures. fCD2 was found to be expressed in feline peripheral blood T lymphocytes, monocytes and cultured lymphoid cells.

Original languageEnglish (US)
Pages (from-to)360-366
Number of pages7
JournalImmunology
Volume105
Issue number3
DOIs
StatePublished - 2002

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Felidae
Erythrocytes
Rosette Formation
Amino Acid Sequence Homology
Monocytes
Cultured Cells
Signal Transduction
Complementary DNA
Monoclonal Antibodies
Lymphocytes
Ligands
T-Lymphocytes
Amino Acids

ASJC Scopus subject areas

  • Immunology

Cite this

Shimojima, M., Nishimura, Y., Miyazawa, T., Kato, K., Nakamura, K., Izumiya, Y., ... Tohya, Y. (2002). A feline CD2 homologue interacts with human red blood cells. Immunology, 105(3), 360-366. https://doi.org/10.1046/j.0019-2805.2001.01371.x

A feline CD2 homologue interacts with human red blood cells. / Shimojima, Masayuki; Nishimura, Yorihiro; Miyazawa, Takayuki; Kato, Kentaro; Nakamura, Kazuya; Izumiya, Yoshihiro; Akashi, Hiroomi; Tohya, Yukinobu.

In: Immunology, Vol. 105, No. 3, 2002, p. 360-366.

Research output: Contribution to journalArticle

Shimojima, M, Nishimura, Y, Miyazawa, T, Kato, K, Nakamura, K, Izumiya, Y, Akashi, H & Tohya, Y 2002, 'A feline CD2 homologue interacts with human red blood cells', Immunology, vol. 105, no. 3, pp. 360-366. https://doi.org/10.1046/j.0019-2805.2001.01371.x
Shimojima M, Nishimura Y, Miyazawa T, Kato K, Nakamura K, Izumiya Y et al. A feline CD2 homologue interacts with human red blood cells. Immunology. 2002;105(3):360-366. https://doi.org/10.1046/j.0019-2805.2001.01371.x
Shimojima, Masayuki ; Nishimura, Yorihiro ; Miyazawa, Takayuki ; Kato, Kentaro ; Nakamura, Kazuya ; Izumiya, Yoshihiro ; Akashi, Hiroomi ; Tohya, Yukinobu. / A feline CD2 homologue interacts with human red blood cells. In: Immunology. 2002 ; Vol. 105, No. 3. pp. 360-366.
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