Abstract
Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 63-69 |
| Number of pages | 7 |
| Journal | Journal of Affective Disorders |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- Family studies
- Good-prognosis schizophrenia
- Lithium response
- Schizoaffective disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
A family study of lithium-responsive psychosis. / Sautter, Frederic J.; McDermott, Barbara E; Garver, David L.
In: Journal of Affective Disorders, Vol. 20, No. 1, 1990, p. 63-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A family study of lithium-responsive psychosis
AU - Sautter, Frederic J.
AU - McDermott, Barbara E
AU - Garver, David L.
PY - 1990
Y1 - 1990
N2 - Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.
AB - Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.
KW - Family studies
KW - Good-prognosis schizophrenia
KW - Lithium response
KW - Schizoaffective disorder
UR - http://www.scopus.com/inward/record.url?scp=0025167060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025167060&partnerID=8YFLogxK
U2 - 10.1016/0165-0327(90)90050-I
DO - 10.1016/0165-0327(90)90050-I
M3 - Article
C2 - 2147191
AN - SCOPUS:0025167060
VL - 20
SP - 63
EP - 69
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1
ER -