A family study of lithium-responsive psychosis

Frederic J. Sautter, Barbara E McDermott, David L. Garver

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalJournal of Affective Disorders
Volume20
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • Family studies
  • Good-prognosis schizophrenia
  • Lithium response
  • Schizoaffective disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

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