Abstract
Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.
Original language | English (US) |
---|---|
Pages (from-to) | 63-69 |
Number of pages | 7 |
Journal | Journal of Affective Disorders |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - 1990 |
Externally published | Yes |
Keywords
- Family studies
- Good-prognosis schizophrenia
- Lithium response
- Schizoaffective disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)