A family study of lithium-responsive psychosis

Frederic J. Sautter; Barbara E McDermott; David L. Garver

doi:10.1016/0165-0327(90)90050-I

A family study of lithium-responsive psychosis

Frederic J. Sautter, Barbara E McDermott, David L. Garver

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.

Original language	English (US)
Pages (from-to)	63-69
Number of pages	7
Journal	Journal of Affective Disorders
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/0165-0327(90)90050-I
State	Published - 1990
Externally published	Yes

Keywords

Family studies
Good-prognosis schizophrenia
Lithium response
Schizoaffective disorder

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

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10.1016/0165-0327(90)90050-I

Cite this

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title = "A family study of lithium-responsive psychosis",

abstract = "Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.",

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year = "1990",

doi = "10.1016/0165-0327(90)90050-I",

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T1 - A family study of lithium-responsive psychosis

AU - Sautter, Frederic J.

AU - McDermott, Barbara E

AU - Garver, David L.

PY - 1990

Y1 - 1990

N2 - Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.

AB - Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P < 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.

KW - Family studies

KW - Good-prognosis schizophrenia

KW - Lithium response

KW - Schizoaffective disorder

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A family study of lithium-responsive psychosis

Abstract

Keywords

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