A facile approach to fabricate self-assembled magnetic nanotheranostics for drug delivery and imaging

Ye Yuan, Yixuan He, Ruonan Bo, Zhao Ma, Zhongling Wang, Lijie Dong, Tzu-Yin Lin, Xiangdong Xue, Yuanpei Li

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles have been extensively employed for theranostic applications due to their good biocompatibility and excellent magnetic resonance imaging (MRI) properties. However, these particles typically require surface modification due to their hydrophobic surfaces caused by the oil-phase surfactants used in the fabrication and thus, the drug loading on their surface is usually limited. Here, we provided a novel and facile approach to conveniently perform surface modification of SPIO while simultaneously loading a large amount of drug. By synthesizing an amphiphilic irinotecan-based compound with a hydrophobic tail enabling insertion into the SPIO assembly, an excellent SPIO-based theranostic nanomedicine (SPIO@IR) was produced. SPIO@IR not only extensively improved the drug efficacy, but also allowed visualization by MRI in biological systems.

Original languageEnglish (US)
Pages (from-to)21634-21639
Number of pages6
JournalNanoscale
Volume10
Issue number46
DOIs
StatePublished - Dec 14 2018

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'A facile approach to fabricate self-assembled magnetic nanotheranostics for drug delivery and imaging'. Together they form a unique fingerprint.

  • Cite this