A cyclic AMP analogue induces synthesis of a myelin-specific glycoprotein by cultured Schwann cells

Neonatal rat Schwann cells, cultured with agents which increase intracellular cyclic AMP, were prompted to resume synthesis of a 170,000 M(r) glycoprotein which is specific to peripheral nervous system myelin and is herein referred to as P(170K). We have shown previously that similar treatment induces the synthesis by Schwann cells of the myelin lipid, galactocerebroside. In contrast to P(170K) and galactocerebroside, syntheses of P₀ and myelin basic protein were not induced. Intracellular cyclic AMP is thus likely to be a participant in the complex system regulating myelination.