A cutting edge overview: Psoriatic disease

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Psoriasis is a lifelong skin disease, affecting about 2% of the global population. Generalized involvement of the body (erythroderma), extensive pustular lesions, and an associated arthritis known as psoriatic arthritis (PsA) are severe complications of psoriasis. Genetic, immunologic, and environmental factors contribute to its pathogenesis. A complete understanding of the pathogenesis of psoriasis and psoriatic arthritis is lacking. Cytokines, chemokines, adhesion molecules, growth factors like NGF, neuropeptides, and T cell receptors all act in an integrated way to evolve into unique inflammatory and proliferative processes typical of psoriasis and PsA. Management of psoriasis requires exemplary skin care along with careful monitoring of arrays of comorbidities which includes arthritis and coronary artery disease. In many ways, psoriasis can be considered a model autoimmune disease. This statement itself is ironic considering that it was not recognized as immune mediated until relatively recently. Fortunately, the immunobiology has made enormous strides and there are now excellent therapeutic options for patients. In this thematic review, we have attempted to provide summaries of not only basic science and clinical research, but also an overview of future research directions.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalClinical Reviews in Allergy and Immunology
Volume44
Issue number2
DOIs
StatePublished - 2013

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Keywords

  • Biologics
  • Epidemiology
  • Imaging
  • Inflammation
  • Psoriasis
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Immunology and Allergy

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