A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome

Heather M. Shapiro, Ling M. Wong, Tony J Simon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with cognitive impairments and significantly elevated risk for developing schizophrenia. While impairments in response inhibition are central to executive dysfunction in schizophrenia, the nature and development of such impairments in children with 22q11.2DS, a group at high risk for the disorder, are not clear. Here we used a classic Go/No-Go paradigm to quantify proactive (anticipatory stopping) and reactive (actual stopping) response inhibition in 47 children with 22q11.2DS and 36 typically developing (TD) children, all ages 7-14. A cross-sectional design was used to examine age-related associations with response inhibition. When compared with TD individuals, children with 22q11.2DS demonstrated typical proactive response inhibition at all ages. By contrast, reactive response inhibition was impaired in children with 22q11.2DS relative to TD children. While older age predicted better reactive response inhibition in TD children, there was no age-related association with reactive response inhibition in children with 22q11.2DS. Closer examination of individual performance data revealed a wide range of performance abilities in older children with 22q11.2DS; some typical and others highly impaired. The results of this cross-sectional analysis suggest an impaired developmental trajectory of reactive response inhibition in some children with 22q11.2DS that might be related to atypical development of neuroanatomical systems underlying this cognitive process. As part of a larger study, this investigation might help identify risk factors for conversion to schizophrenia and lead to early diagnosis and preventive intervention.

Original languageEnglish (US)
Article numberArticle 81
JournalFrontiers in Psychiatry
Volume4
Issue numberAUG
DOIs
StatePublished - 2013

Fingerprint

DiGeorge Syndrome
Chromosome Deletion
Cross-Sectional Studies
Reactive Inhibition
Schizophrenia
Proactive Inhibition
Inhibition (Psychology)
Aptitude
Early Diagnosis

Keywords

  • 22q11.2 deletion syndrome
  • Childhood cognitive development
  • Developmental disorders
  • Executive function
  • Response inhibition

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome. / Shapiro, Heather M.; Wong, Ling M.; Simon, Tony J.

In: Frontiers in Psychiatry, Vol. 4, No. AUG, Article 81, 2013.

Research output: Contribution to journalArticle

@article{e0ee34e33a024a7a83532886e3bd223e,
title = "A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome",
abstract = "Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with cognitive impairments and significantly elevated risk for developing schizophrenia. While impairments in response inhibition are central to executive dysfunction in schizophrenia, the nature and development of such impairments in children with 22q11.2DS, a group at high risk for the disorder, are not clear. Here we used a classic Go/No-Go paradigm to quantify proactive (anticipatory stopping) and reactive (actual stopping) response inhibition in 47 children with 22q11.2DS and 36 typically developing (TD) children, all ages 7-14. A cross-sectional design was used to examine age-related associations with response inhibition. When compared with TD individuals, children with 22q11.2DS demonstrated typical proactive response inhibition at all ages. By contrast, reactive response inhibition was impaired in children with 22q11.2DS relative to TD children. While older age predicted better reactive response inhibition in TD children, there was no age-related association with reactive response inhibition in children with 22q11.2DS. Closer examination of individual performance data revealed a wide range of performance abilities in older children with 22q11.2DS; some typical and others highly impaired. The results of this cross-sectional analysis suggest an impaired developmental trajectory of reactive response inhibition in some children with 22q11.2DS that might be related to atypical development of neuroanatomical systems underlying this cognitive process. As part of a larger study, this investigation might help identify risk factors for conversion to schizophrenia and lead to early diagnosis and preventive intervention.",
keywords = "22q11.2 deletion syndrome, Childhood cognitive development, Developmental disorders, Executive function, Response inhibition",
author = "Shapiro, {Heather M.} and Wong, {Ling M.} and Simon, {Tony J}",
year = "2013",
doi = "10.3389/fpsyt.2013.00081",
language = "English (US)",
volume = "4",
journal = "Frontiers in Psychiatry",
issn = "1664-0640",
publisher = "Frontiers Research Foundation",
number = "AUG",

}

TY - JOUR

T1 - A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome

AU - Shapiro, Heather M.

AU - Wong, Ling M.

AU - Simon, Tony J

PY - 2013

Y1 - 2013

N2 - Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with cognitive impairments and significantly elevated risk for developing schizophrenia. While impairments in response inhibition are central to executive dysfunction in schizophrenia, the nature and development of such impairments in children with 22q11.2DS, a group at high risk for the disorder, are not clear. Here we used a classic Go/No-Go paradigm to quantify proactive (anticipatory stopping) and reactive (actual stopping) response inhibition in 47 children with 22q11.2DS and 36 typically developing (TD) children, all ages 7-14. A cross-sectional design was used to examine age-related associations with response inhibition. When compared with TD individuals, children with 22q11.2DS demonstrated typical proactive response inhibition at all ages. By contrast, reactive response inhibition was impaired in children with 22q11.2DS relative to TD children. While older age predicted better reactive response inhibition in TD children, there was no age-related association with reactive response inhibition in children with 22q11.2DS. Closer examination of individual performance data revealed a wide range of performance abilities in older children with 22q11.2DS; some typical and others highly impaired. The results of this cross-sectional analysis suggest an impaired developmental trajectory of reactive response inhibition in some children with 22q11.2DS that might be related to atypical development of neuroanatomical systems underlying this cognitive process. As part of a larger study, this investigation might help identify risk factors for conversion to schizophrenia and lead to early diagnosis and preventive intervention.

AB - Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with cognitive impairments and significantly elevated risk for developing schizophrenia. While impairments in response inhibition are central to executive dysfunction in schizophrenia, the nature and development of such impairments in children with 22q11.2DS, a group at high risk for the disorder, are not clear. Here we used a classic Go/No-Go paradigm to quantify proactive (anticipatory stopping) and reactive (actual stopping) response inhibition in 47 children with 22q11.2DS and 36 typically developing (TD) children, all ages 7-14. A cross-sectional design was used to examine age-related associations with response inhibition. When compared with TD individuals, children with 22q11.2DS demonstrated typical proactive response inhibition at all ages. By contrast, reactive response inhibition was impaired in children with 22q11.2DS relative to TD children. While older age predicted better reactive response inhibition in TD children, there was no age-related association with reactive response inhibition in children with 22q11.2DS. Closer examination of individual performance data revealed a wide range of performance abilities in older children with 22q11.2DS; some typical and others highly impaired. The results of this cross-sectional analysis suggest an impaired developmental trajectory of reactive response inhibition in some children with 22q11.2DS that might be related to atypical development of neuroanatomical systems underlying this cognitive process. As part of a larger study, this investigation might help identify risk factors for conversion to schizophrenia and lead to early diagnosis and preventive intervention.

KW - 22q11.2 deletion syndrome

KW - Childhood cognitive development

KW - Developmental disorders

KW - Executive function

KW - Response inhibition

UR - http://www.scopus.com/inward/record.url?scp=84884489046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884489046&partnerID=8YFLogxK

U2 - 10.3389/fpsyt.2013.00081

DO - 10.3389/fpsyt.2013.00081

M3 - Article

VL - 4

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

IS - AUG

M1 - Article 81

ER -